XRCC4 rs6869366 polymorphism is associated with susceptibility to both nicotine dependence and/or schizophrenia

Authors

  • Sacide Pehlivan Istanbul University. Istanbul Faculty of MedicineDepartment of Medical Biology
  • Mehmet Atilla Uysal Yedikule Hospital for Chest Diseases and Thoracic Surgery Training and Research Hospital
  • Nazan Aydin Yedikule Hospital for Chest Diseases and Thoracic Surgery Training and Research Hospital
  • Ayse Feyda Nursal Hitit University, Faculty of Medicine, Department of Medical Genetics
  • Mustafa Pehlivan Gaziantep Univesity, Faculty of Medicine, Department of Haematology
  • Hazal Yavuzlar Bakirkoy Research and Training Hospital for Psychiatry
  • Ulgen Sever Istanbul University, Istanbul Faculty of Medicine
  • Selin Kurnaz Istanbul University, Istanbul Faculty of Medicine
  • Fatih Kasım Yavuz Yedikule Hospital for Chest Diseases and Thoracic Surgery Training and Research Hospital
  • Suna Uysal Yedikule Hospital for Chest Diseases and Thoracic Surgery Training and Research Hospital
  • Pinar Cetinay Aydin Bakirkoy Research and Training Hospital for Psychiatry

DOI:

https://doi.org/10.1590/acp.v45i3.152981

Keywords:

DNA repair, Schizophrenia, nicotine dependence, XRCC4

Abstract

Background: Oxidative stress induced DNA damage has been assumed to contribute to the etiopathogenesis of schizophrenia (Sch). Smoking prevalence was more common in patients with Sch. The X-ray repair cross-complementation group 4 (XRCC4) gene plays an important role in the repair of DNA double-strand breaks. Objective: The purpose of this study was to investigate whether XRCC4 rs6869366 polymorphism has a relationship both in nicotine dependence (ND) and Sch+ND risk. Methods: One hundred and four patients with Sch+ND, 133 subjects with ND only and 70 healthy controls were enrolled in the study. XRCC4 rs6869366 polymorphism was analyzed using PCR-RFLP assay. Results: The frequency of XRCC4 rs6869366 GG genotype was more common in the ND and Sch+ND group than controls (p = 0.001 and p = 0.001, respectively). XRCC4 rs6869366 TT genotype was lower in both ND and Sch+ND group compared to controls (p = 0.001 and p = 0.001, respectively). Also, XRCC4 rs6869366 G allele was higher in Sch+ND group than controls (p = 0.001) while XRCC4 rs6869366 T allele was lower in ND group than healthy controls (p=0.001). XRCC4 rs6869366 GT genotype was lower in ND group than control group (p = 0.003). Discussion: These results suggested that the XRCC4 rs6869366 polymorphism G related genotype/allele was associated with susceptibility to both ND and Sch+ND in a Turkish population.

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Published

2018-12-19

Issue

Vol. 45 No. 3 (2018)

Section

Original Articles

License

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How to Cite

XRCC4 rs6869366 polymorphism is associated with susceptibility to both nicotine dependence and/or schizophrenia. (2018). Archives of Clinical Psychiatry, 45(3), 53-56. https://doi.org/10.1590/acp.v45i3.152981