Trazodone: pharmacology and drug interactions

Authors

  • Maria da Graça Cantarelli Pontifícia Universidade Católica do Rio Grande do Sul; HSL; Ambulatório de Depressão
  • Marco Antonio Marcolin Pontifícia Universidade Católica do Rio Grande do Sul; HSL; Ambulatório de Depressão

DOI:

https://doi.org/10.1590/S0101-60832006000600006

Keywords:

Trazodone, pharmacology, drug interaction, adverse drug reaction, cytochrome P450

Abstract

BACKGROUND: Trazodone is an atypical antidepressant with further therapeutic effects on anxiety and sleep disorders. OBJECTIVE: To review the pharmacokinetic and pharmacodynamic properties of trazodone in order to better understand the potential of adverse events related to drug interactions. METHODS: Electronic search of Medline and High Wire Press databases using the keywords: "trazodone", "adverse drug reaction", and "drug interaction". Additional references were obtained from pharmacology textbooks. RESULTS: A comprehensive data set on the pharmacological profile of trazodone was obtained. CONCLUSION: Trazodone is being increasedly prescribed no only to depressive and sleep disorders, but also in certain sexual dysfunctions. The risk of adverse events due to drug interactions is acceptable and manageable, rendering trazodone a useful tool in the treatment of psychiatric and related disorders.

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Published

2006-01-01

Issue

Vol. 33 No. 6 (2006)

Section

Reviews of Literature

License

Once accepted for publication, the manuscript becomes permanent property of the Archives of Clinical Psychiatry. This copyright transfer subsumes exclusive and unlimited entitlement of the Archives of Clinical Psychiatry to publish and distribute the full contents of articles in whichever publishing medium, including press and electronic media, in Brazil and abroad.

Manuscripts are accepted with the understanding that the Editor and the editorial staff have the right to make revisions aimed at greater conciseness, clarity, and conformity with Journal style, of course without changing its content.

How to Cite

Trazodone: pharmacology and drug interactions . (2006). Archives of Clinical Psychiatry, 33(6), 329-336. https://doi.org/10.1590/S0101-60832006000600006