Vascular depression in elderly: response to treatment with antidepressant associated to cholinesterase inhibitor

Authors

  • Ricardo Barcelos Universidade de São Paulo; Faculdade de Medicina; Hospital das Clínicas; Instituto de Psiquiatria
  • Juliano Faria Universidade Federal de São Paulo; Escola Paulista de Medicina
  • Paulo Grossi Hospital Geral Santa Lúcia; Centro de Terapia Intensiva
  • Marco Antonio Moscoso Aparício Universidade de São Paulo; Faculdade de Medicina; Hospital das Clínicas; Instituto de Psiquiatria
  • Cássio M. C. Bottino USP; FM; Departamento de Psiquiatria

DOI:

https://doi.org/10.1590/S0101-60832007000600006

Keywords:

Vascular depression, vascular dementia, Alzheimer's disease, stroke, neuroimaging

Abstract

CONTEXT: Among neuropsychiatric disorders caused by cerebrovascular factors, vascular depression is diagnosed in a small degree by general practitioners, causing morbid-mortality increase in elderly. CASE REPORT: That is a case of a 67 year-old-man with partial response after treatment with a Selective Serotonin Receptors Inhibitor, and severe autonomic adverse effects with other antidepressants. The addition of rivastigmine to citalopram resulted in a therapeutic success, with a reduction of 23 to 7 points on the Hamilton Depressive Scale (HAM-D). DISCUSSION: The result obtained brings new perspectives to the treatment of vascular depression, providing that randomized controlled trials with larger sample sizes confirm the positive effect of the addition of a cholinesterase inhibitor to antidepressants in the treatment of these patients.

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Published

2007-01-01

Issue

Vol. 34 No. 6 (2007)

Section

Case Report

License

Once accepted for publication, the manuscript becomes permanent property of the Archives of Clinical Psychiatry. This copyright transfer subsumes exclusive and unlimited entitlement of the Archives of Clinical Psychiatry to publish and distribute the full contents of articles in whichever publishing medium, including press and electronic media, in Brazil and abroad.

Manuscripts are accepted with the understanding that the Editor and the editorial staff have the right to make revisions aimed at greater conciseness, clarity, and conformity with Journal style, of course without changing its content.

How to Cite

Vascular depression in elderly: response to treatment with antidepressant associated to cholinesterase inhibitor . (2007). Archives of Clinical Psychiatry, 34(6), 290-293. https://doi.org/10.1590/S0101-60832007000600006