Post-stroke depression: psychological, neuropsychological, HHA axis, localization of stroke aspects and treatment

Authors

  • Luisa de Marillac Niro Terroni Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Patricia Ferreira Mattos Universidade de São Paulo; Hospital da Clínicas da Faculdade de Medicina; Departamento e Instituto de Psiquiatria; Grupo de Interconsultas
  • Matildes de Freitas Menezes Sobreiro HC-FMUSP; Instituto Central; Divisão de Psicologia
  • Valeri Delgado Guajardo Universidade de São Paulo; Hospital da Clínicas da Faculdade de Medicina; Departamento e Instituto de Psiquiatria; Grupo de Interconsultas
  • Renério Fráguas Harvard Medical School; Massachusetts General Hospital; Research Program; Depression Clinical

DOI:

https://doi.org/10.1590/S0101-60832009000900006

Keywords:

post-stroke depression, stroke, depression, quality of life, cognitive dysfunction, hypercortisolism, treatment

Abstract

BACKGROUND: The prevalence of post-stroke depression (PSD) is elevated. Some risk factors and poor outcome have been associated with PSD. The treatment of PSD reduced the negative impact in patients recovery. Appart from these data the PSD has been under diagnosed and under treated. OBJECTIVE: Review some aspects such as quality of life, cognitive dysfunction, hypercortisolism, stroke localization and treatment of PSD. METHODS: MedLine/PubMed database search using the terms post-stroke depression, stroke, quality of life, hypercortisolism, cognitive dysfunction and treatment, published in MedLine in the last 10 years. RESULTS: PSD has a high rate of prevalence, from 23% to 60%. Few incidence rates are investigated. PSD is associated with poor outcome, increase of cognitive dysfunction and reduced quality of life. The hypercortisolism seems to be associated with PSD in the latter period of stroke. Stroke in the left frontal region, basal ganglia and some structures of prefrontosubcortical circuits have been related with frequency and severity of PSD. DISCUSSION: Some programs can be used to assist the medical care researcher with these patients in diagnosis and treatment of PSD. The research needs to be continued with clear methodological protocols in order to understand the physiopathology related to the incident PSD.

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Published

2009-01-01

Issue

Vol. 36 No. supl.3 (2009)

Section

Reviews of Literature

License

Once accepted for publication, the manuscript becomes permanent property of the Archives of Clinical Psychiatry. This copyright transfer subsumes exclusive and unlimited entitlement of the Archives of Clinical Psychiatry to publish and distribute the full contents of articles in whichever publishing medium, including press and electronic media, in Brazil and abroad.

Manuscripts are accepted with the understanding that the Editor and the editorial staff have the right to make revisions aimed at greater conciseness, clarity, and conformity with Journal style, of course without changing its content.

How to Cite

Post-stroke depression: psychological, neuropsychological, HHA axis, localization of stroke aspects and treatment . (2009). Archives of Clinical Psychiatry, 36(supl.3), 100-108. https://doi.org/10.1590/S0101-60832009000900006