Adverse reaction caused by drugs acting in nervous system: records analysis of a farmacovigilance center in Brazil

  • Marta Maria de França Fonteles UFC; Faculdade de Farmácia, Odontologia e Enfermagem; Curso de Farmácia; Grupo de Prevenção ao Uso Indevido de Medicamentos
  • Eudiana Vale Francelino UFC; Faculdade de Farmácia, Odontologia e Enfermagem; Curso de Farmácia; Grupo de Prevenção ao Uso Indevido de Medicamentos
  • Luciana Kelly Ximenes dos Santos Universidade Federal do Ceará; Faculdade de Medicina
  • Karla Marques Silva UFC; Faculdade de Farmácia, Odontologia e Enfermagem; Curso de Farmácia; Grupo de Prevenção ao Uso Indevido de Medicamentos
  • Rodrigo Siqueira Universidade Federal do Ceará; Faculdade de Medicina
  • Glauce Socorro de Barros Viana Universidade Federal do Ceará; Faculdade de Medicina
  • Silvânia Maria Mendes de Vasconcelos Universidade Federal do Ceará; Faculdade de Medicina
  • Francisca Cléa Florenço de Sousa Universidade Federal do Ceará; Faculdade de Medicina
  • Mirian Parente Monteiro UFC; Faculdade de Farmácia, Odontologia e Enfermagem; Curso de Farmácia; Grupo de Prevenção ao Uso Indevido de Medicamentos
Keywords: Adverse reaction, medicines, nervous system, pharmacovigilance

Abstract

BACKGROUND: The morbi-mortality by the use of medicines is a major health problem. The drug adverse reactions may result in death, increased hospitalizations and healthcare costs. OBJECTIVES: Describe and analyze reports of suspected adverse reactions caused by drugs that act on the nervous system (SN-ADR), registered in the database of the Pharmacovigilance Centre of Ceará, from January 1997 to March 2008. METHODS: All the NS-ADRs were classified according to criteria of the World Health Organization. The causality between the drug administered and the adverse reaction was established, as well as the analysis regarding to the severity of the reaction. RESULTS: The Centre recorded 176 notifications of RAM-SN. The most of the reactions occurred in the hospital. The main reporter was the pharmacist. All the RAM-SN were classified as possible (n = 110), probable (n = 37) and definite (n = 17). With regard to severity, the NS-ADRs were considered: light (n = 21), moderate (n = 127), serious (n = 15) and fatal (n = 1). The fatal case was reported by physician, and involved anesthetic drugs. In general the adverse reactions observed were caused predominantly by analgesics, anesthetics and antiepileptics. DISCUSSION: The data demonstrate the potential values of accessing to a local system of pharmacovigilance to report possible risks with the use of nervous system drugs.

Downloads

Download data is not yet available.
Published
2009-01-01
How to Cite
Fonteles, M., Francelino, E., Santos, L., Silva, K., Siqueira, R., Viana, G., Vasconcelos, S., Sousa, F., & Monteiro, M. (2009). Adverse reaction caused by drugs acting in nervous system: records analysis of a farmacovigilance center in Brazil . Archives of Clinical Psychiatry, 36(4), 137-144. https://doi.org/10.1590/S0101-60832009000400003
Section
Original Articles