Manic/hypomanic symptoms induced by aripiprazole

Authors

  • Márcio Gerhardt Soeiro de Souza Universidade de São Paulo; Faculdade de Medicina; Hospital das Clínicas; Instituto de Psiquiatria Grupo de Estudos de Doenças Afetivas
  • Carlos Henrique Rodrigues dos Santos Universidade de São Paulo; Faculdade de Medicina; Hospital das Clínicas; Instituto de Psiquiatria Grupo de Estudos de Doenças Afetivas
  • Ricardo Alberto Moreno Universidade de São Paulo; Faculdade de Medicina; Hospital das Clínicas; Instituto de Psiquiatria Grupo de Estudos de Doenças Afetivas

DOI:

https://doi.org/10.1590/S0101-60832010000400006

Keywords:

Bipolar disorder, bipolar depression, mania, aripiprazole, side effects

Abstract

Aripiprazole is an atypical antipsychotic often used as monotherapy or as add-on therapy in patients with manic episodes, as well as for bipolar disorders. The antidepressive effect of the atypical antipsychotic medications raises the possibility that these drugs may increase the risk of mania in susceptible individuals. With the aim of providing further evidence on this subject, herein we reported three patients with bipolar disorder and mania induced by aripiprazole. Patients had different final diagnosis as well as different comorbidities. Their therapeutic regimen was different as well. Onset of manias was temporarily associated with aripiprazole use and important improvement happened after the discontinuation of this drug. We suggest that aripiprazole, due to its antidepressant properties, is a risk factor for mania and hypomania. Mood stabilizer is recommended in certain individuals using this drug, in order to prevent phase switch. We also suggest the antidepressant efficacy of aripiprazole.

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Published

2010-01-01

Issue

Vol. 37 No. 4 (2010)

Section

Case Reports

License

Once accepted for publication, the manuscript becomes permanent property of the Archives of Clinical Psychiatry. This copyright transfer subsumes exclusive and unlimited entitlement of the Archives of Clinical Psychiatry to publish and distribute the full contents of articles in whichever publishing medium, including press and electronic media, in Brazil and abroad.

Manuscripts are accepted with the understanding that the Editor and the editorial staff have the right to make revisions aimed at greater conciseness, clarity, and conformity with Journal style, of course without changing its content.

How to Cite

Manic/hypomanic symptoms induced by aripiprazole . (2010). Archives of Clinical Psychiatry, 37(4), 175-177. https://doi.org/10.1590/S0101-60832010000400006