Genetic association studies in obsessive-compulsive disorder

Authors

  • Aline Santos Sampaio Universidade Federal da Bahia; Serviço Médico Universitário Dr. Rubens Brasil
  • Rita Márcia Pacheco Lins UFBA; Faculdade de Medicina; Departamento de Neurociências e Saúde Mental
  • Renato Daltro-Oliveira UFBA; Faculdade de Medicina; Departamento de Neurociências e Saúde Mental
  • Lucas de Castro Quarantini UFBA; Faculdade de Medicina; Departamento de Neurociências e Saúde Mental
  • Maria Conceição do Rosário Universidade Federal de São Paulo; Departamento de Psiquiatria
  • Eurípedes Constantino Miguel Universidade de São Paulo; Faculdade de Medicina; Departamento e Instituto de Psiquiatria
  • Ana Gabriela Hounie Universidade de São Paulo; Faculdade de Medicina; Departamento e Instituto de Psiquiatria

DOI:

https://doi.org/10.1590/S0101-60832013000500003

Abstract

BACKGROUND: Obsessive-compulsive disorder (OCD) segregates in families. It follows a complex model of genetic transmission, which involves the influence of several small effect genes interacting with the environment. METHODS: A systematic review of genetic association studies in OCD was performed. Articles published until 2012 were searched in the databases PubMed, Embase and SciELO using the terms of MeSH and its associates or synonyms for "obsessive-compulsive disorder", "gene" and "genetic association studies". RESULTS: We selected 105 papers and described their main results grouped as genes related to: serotonin, dopamine, glutamate, GABA, white matter, immune system, hormones and other genes. CONCLUSION: There is high variability between findings of association studies among the several candidate genes studied in OCD. Glutamate-related genes are promising candidates for OCD, but there is no conclusive association between any of the candidate genes studied and OCD. Association studies with large sample size, evaluation of more homogeneous subgroups of phenotype and meta-analyses are still needed.

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Published

2013-01-01

Issue

Vol. 40 No. 5 (2013)

Section

Review Article

License

Once accepted for publication, the manuscript becomes permanent property of the Archives of Clinical Psychiatry. This copyright transfer subsumes exclusive and unlimited entitlement of the Archives of Clinical Psychiatry to publish and distribute the full contents of articles in whichever publishing medium, including press and electronic media, in Brazil and abroad.

Manuscripts are accepted with the understanding that the Editor and the editorial staff have the right to make revisions aimed at greater conciseness, clarity, and conformity with Journal style, of course without changing its content.

How to Cite

Genetic association studies in obsessive-compulsive disorder . (2013). Archives of Clinical Psychiatry, 40(5), 177-190. https://doi.org/10.1590/S0101-60832013000500003