Occurrence of mesothelial/monocytic incidental cardiac excrescences in material from open-heart procedures: case reports and literature review

  • Vitor Gabriel Ribeiro Grossi University of São Paulo (USP), School of Medicine, Department of Anatomic Pathology
  • Karen Lee University of São Paulo (USP), School of Medicine, Department of Anatomic Pathology
  • Léa Maria Demarchi University of São Paulo (USP), School of Medicine, Heart Institute, Laboratory of Pathology
  • Jussara Bianchi Castelli University of São Paulo (USP), School of Medicine, Heart Institute, Laboratory of Pathology
  • Vera Demarchi Aiello University of São Paulo (USP), School of Medicine, Heart Institute, Laboratory of Pathology
Keywords: Heart DiseasesIncidental FindingsEpitheliumHistiocytes.

Abstract

Mesothelial/monocytic incidental cardiac excrescences (MICE) are unusual findings during the histological analysis of material from the pericardium, mediastinum, or other tissues collected in open-heart surgery. Despite their somewhat worrisome histological appearance, they show a benign clinical course, and further treatment is virtually never necessary. Hence, the importance of recognizing the entity relays in its differential diagnosis, as an unaware medical pathologist may misinterpret it for a malignant neoplasm. Other mesothelial and histiocytic proliferative lesions, sharing very close histological morphology and immunohistochemistry features with MICE, have been described in sites other than the heart or the mediastinum. This similarity has led to the proposal of the common denomination “histiocytosis with raisinoid nuclei.” We report three cases from the pathology archives of the Heart Institute of São Paulo University (Incor/HC-FMUSP), diagnosed as “mesothelial/monocytic incidental cardiac excrescence,” with immunohistochemical documentation, and provide a literature review of this entity.

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Published
2018-03-13
How to Cite
Grossi, V., Lee, K., Demarchi, L. M., Castelli, J., & Aiello, V. (2018). Occurrence of mesothelial/monocytic incidental cardiac excrescences in material from open-heart procedures: case reports and literature review. Autopsy and Case Reports, 8(1), e2018002. https://doi.org/10.4322/acr.2018.002
Section
Article / Clinical Case Report