Primary endometrial large cell neuroendocrine carcinoma with melanocytic differentiation

  • Lucinda Calheiros Guimarães Federal University of Triângulo Mineiro
  • Priscila Leandro Garcia Federal University of Triângulo Mineiro
  • João Badaró Castro Filho Federal University of Triângulo Mineiro
  • Antonio Carlos Oliveira Meneses Federal University of Triângulo Mineiro
Keywords: Endometrium, Carcinoma, Neuroendocrine, Carcinoma Large Cell, Melanocytes, Immunohistochemistry

Abstract

High-grade endometrial carcinomas are aggressive neoplasms of difficult histological classification. Neuroendocrine differentiation in endometrial carcinomas is rare. This is the report of an endometrial large cell neuroendocrine carcinoma with foci of melanocytic differentiation in a 75-year-old woman with abnormal post-menopausal uterine bleeding for 2 years. Two initial biopsies were inconclusive. Histopathological examination of the uterus revealed large cell neuroendocrine carcinoma associated with endometrioid carcinoma and foci of melanocytic differentiation, pT3a (FIGO IIIA). There were metastases in the rectum serosa and lungs. After 8 months of diagnosis and surgical treatment, the patient is on chemotherapy and radiotherapy. We highlight the morphological characteristics and criteria that allow the definitive anatomopathological diagnosis, including immunohistochemical markers used to identify the cell types present in this unprecedented association.

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Published
2018-11-12
How to Cite
Guimarães, L., Garcia, P., Castro Filho, J. B., & Meneses, A. C. (2018). Primary endometrial large cell neuroendocrine carcinoma with melanocytic differentiation. Autopsy and Case Reports, 8(4), e2018041. Retrieved from http://www.revistas.usp.br/autopsy/article/view/151733
Section
Article / Clinical Case Report