Early stage primary gastric diffuse large B-cell lymphoma in a young HIV-positive patient

  • Guilherme Harada Department of Internal Medicine - Faculdade de Medicina - Universidade de São Paulo, São Paulo/SP
  • Aloisio Felipe-Silva Anatomic Pathology Service - Hospital Universitário - Universidade de São Paulo, São Paulo/SP
  • José Guilherme Nogueira da Silva Endoscopy Service - Hospital Universitário - Universidade de São Paulo, São Paulo/SP
Keywords: Lymphoma, Large B-Cell, Diffuse, Stomach Neoplasms, AIDS-Related, Acquired Immunodeficiency Syndrome

Abstract

HIV infection is known to be associated with the development of a wide range of neoplasia. About 25 to 40% of HIV-positive patients will present some kind of malignancy in the course of the disease; among them 10% are non-Hodgkin lymphomas (NHL) and 20% of these are represented by the diffuse large B-cell lymphoma. HIV-positive patients have a relative risk of 110 times higher to develop neoplasia, than the non-infected population. The gastrointestinal (GI) tract is the most frequent extranodal site of involvement. However, the primary GI lymphoma is rare. The authors present a case of a 31-year-old male patient with a 16-year history of HIV infection, who deliberately withdrew the Highly Active Antiretroviral Therapy (HAART) regimen and was hospitalized because of a respiratory infection. Because of a long-term complaint of dyspepsia, an upper gastrointestinal endoscopy was performed disclosing a large elevated and ulcerated gastric lesion, which biopsy revealed a diffuse large B-cell lymphoma. Clinical, imaging and laboratory tests showed an early stage diagnosis: Lugano stage I. Although not frequent, the authors alert to considering this neoplasia in all HIV-positive patients with dyspeptic symptoms.

Downloads

Download data is not yet available.
Published
2014-06-26
How to Cite
Harada, G., Felipe-Silva, A., & Silva, J. (2014). Early stage primary gastric diffuse large B-cell lymphoma in a young HIV-positive patient. Autopsy and Case Reports, 4(2), 49-54. https://doi.org/10.4322/acr.%y.82535
Section
Article / Clinical Case Report