Preclinical evaluation of nephroprotective potential of a probiotic formulation LOBUN on Cyclosporine-A induced renal dysfunction in Wistar rats

Authors

  • Kambham Venkateswarlu JNTUA Oil Technological and Pharmaceutical Research Institute; Department of Pharmaceutics
  • Thakur Heerasingh Cognizant Technology Solutions
  • Chilamakuru Naresh Babu Raghavendra Institute of Pharmaceutical Education and Research; Department of Pharmaceutical Chemistry
  • Singirisetty Triveni Raghavendra Institute of Pharmaceutical Education and Research; Department of Pharmaceutical Chemistry
  • Suroju Manasa Vikas College of Pharmacy; Department of Pharmaceutics
  • Thumati Nagendra Bhaskar Babu QA Executive, FR&D, Aurobindo Pharma Ltd

DOI:

https://doi.org/10.1590/s2175-97902017000216041

Keywords:

Cyclosporine-A, LOBUN/effects, LOBUN/effects/evaluation, Nephroprotective activity, Prebiotics, Probiotics, Chronic Kidney Disease/study

Abstract

The aim of present study was to evaluate the nephroprotective effect of probiotic formulation LOBUN on Cyclosporine A (CsA) induced renal dysfunction in Wistar rats. CsA (20 mg/kg body weight s.c) was administered for 15 days to cause renal dysfunction in Wistar rats. The probiotic formulation LOBUN was administered with the dose of 500 mg/kg body weight (p.o) for twice (TGI) and thrice a day (TGII). The samples were analyzed for the parameters like blood urine nitrogen (BUN), serum creatinine, serum uric acid, total serum protein and urine proteins, urine potassium, urine sodium. The renal functional and histopathological studies revealed that the oral administration of probiotic formulation LOBUN has provided appreciable renoprotection and possibly alleviated the symptoms of Chronic Kidney Disease (CKD) at the dose of 500 mg/kg body weight administered thrice a day and also the results were supported by histopathological findings.

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Published

2017-01-01

Issue

Vol. 53 No. 2 (2017)

Section

Articles

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on line journal has open and free access.

How to Cite

Preclinical evaluation of nephroprotective potential of a probiotic formulation LOBUN on Cyclosporine-A induced renal dysfunction in Wistar rats. (2017). Brazilian Journal of Pharmaceutical Sciences, 53(2), e16041-. https://doi.org/10.1590/s2175-97902017000216041