Analysis of the presence of FLT3 gene mutation and association with prognostic factors in adult and pediatric acute leukemia patients

Authors

  • Graciele Burnatt Federal University of Santa Catarina; Health Sciences Centre; Department of Clinical Analyses
  • Marley Aparecida Licínio Federal University of Santa Catarina; Health Sciences Centre; Department of Clinical Analyses
  • Pâmela Cristina Gaspar Federal University of Santa Catarina; Health Sciences Centre; Department of Clinical Analyses
  • Arthur Schveitzer Ferreira Federal University of Santa Catarina; Health Sciences Centre; Department of Clinical Analyses
  • Manoela Lira Reis Federal University of Santa Catarina; Health Sciences Centre; Department of Clinical Analyses
  • Ana Carolina Rabello de Moraes Federal University of Santa Catarina; Health Sciences Centre; Department of Clinical Analyses
  • Thaís Cristine Marques Sincero Federal University of Santa Catarina; Health Sciences Centre; Department of Clinical Analyses
  • Maria Cláudia Santos-Silva Federal University of Santa Catarina; Health Sciences Centre; Department of Clinical Analyses

DOI:

https://doi.org/10.1590/s2175-97902017000216105

Keywords:

FLT3-ITD/mutation, Acute leucemia/prognostic factors, Acute leucemia/adults patients, Acute leucemia/pediatric patients, AML, ALL, FLT3-D835.

Abstract

When the FLT3 gene is mutated, it originates a modified receptor with structural changes, which give survival advantage and malignant hematopoietic cell proliferation. Thus, the presence of mutations in this gene is considered an unfavorable prognostic factor. A total of 85 consecutive samples of newly diagnosed untreated patients with AL were included in the study after they provided their informed consent. FLT3 gene mutations were detected by PCR. For the pediatric group, a positive correlation was observed between WBC count and the presence of FLT3-ITD in patients with AML and ALL. Furthermore, children with AML who had the FLT3-ITD mutation showed a tendency to express CD34 in blast cells. In the adult group, the AML patients with FLT3-ITD who expressed CD34 in blast cells had a tendency to worse progression. The present data indicate no association between the prognostic factors evaluated and FLT3 gene mutations in adult with AL. Yet, the presence of FLT3-ITD mutation was significantly related with WBC count in the pediatric group. These findings demonstrate that FLT3 gene mutations can be considered as independent poor prognostic factors.

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Published

2017-01-01

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Section

Articles

How to Cite

Analysis of the presence of FLT3 gene mutation and association with prognostic factors in adult and pediatric acute leukemia patients. (2017). Brazilian Journal of Pharmaceutical Sciences, 53(2), e16105-. https://doi.org/10.1590/s2175-97902017000216105