Effect of wet mass on dextromethorphan hydrobromide matrix pellets

  • Mohamed Abbas Ibrahim King Saud University, College of Pharmacy, Department of Pharmaceutics
  • Gamal Mohamed Mahrous King Saud University, College of Pharmacy, Department of Pharmaceutics
Keywords: Dextromethorphan hydrobromide, Matrix pellets, Extrusion spheronization, Mix torque rheometer (MTR)

Abstract

Dextromethorphan hydrobromide (DM) sustained release matrix pellets containing 10% w/w drug were prepared by an extrusion/spheronization technique. The effect of mixing different concentrations of ethyl cellulose (EC), hydroxypropyl methylcellulpse (HPMC K10), and Carbopol 934 with Avicel PH101 on the rheological properties of pellet wet mass was evaluated using mixer torque rheometry (MTR). The prepared pellets were characterized for size, drug content, and in-vitro DM release rate. The results showed that increasing the concentration of the hydrophobic polymer (EC) with Avicel PH101 decreased wet mass consistency, represented by mass mean line torque. Lower binder ratio was required for optimum wet massing, while mixing with swellable polymers (HPMC and Carbopol) caused a noticeable increase in both mean line torque and binder ratio. Combinations of HPMC and Carbopol at higher concentrations resulted in controlled in vitro release of DM from the prepared pellets. Furthermore, mathematical treatment of the in vitro release data of DM from the prepared pellets showed that all formulations except those containing 5% Carbopol plus 5% HPMC (F10) follow first order release. n values of these formulation were in the range of 0.09-0.40, which support an anomalous non-Fickian release.

Downloads

Download data is not yet available.
Published
2018-12-20
How to Cite
Ibrahim, M., & Mahrous, G. (2018). Effect of wet mass on dextromethorphan hydrobromide matrix pellets. Brazilian Journal of Pharmaceutical Sciences, 54(4), e00228. https://doi.org/10.1590/s2175-97902018000400228
Section
Articles