Development and evaluation of multiparticulate biphasic system for the treatment of circadian diseases

  • Sarah Moherdaui Martins State University of the West of Paraná, Department of Pharmacy
  • Vinicius Müller Prati-Donaduzzi and Cia Ltda, Development and Innovation, Department of Research
  • Vanderson Galan Prati-Donaduzzi and Cia Ltda, Development and Innovation, Department of Research
  • Fabio Pinheiro de Souza Prati-Donaduzzi and Cia Ltda, Development and Innovation, Department of Research
  • Itamar Francisco Andreazza Federal University of Parana, Department of Pharmacy
  • Maurício Ferreira da Rosa State University of the West of Paraná, Department of Pharmacy
Keywords: Chronotherapy, Biphasic Release, Pellets, Cellulosic Polymers, Experimental Design

Abstract

Multiparticulate systems have biopharmaceutical advantages when compared to the monolithic systems, once they allow different patterns of drug release and can be used in different treatments. The aim of the present work was to develop a biphasic controlled release delivery system, using propranolol hydrochloride (PROP) that can be used for the treatment of circadian diseases. This system was obtained by the combination of cellulosic polymers hydroxypropyl methylcellulose (HPMC) and ethylcellulose (EC) in a 2² factorial experimental design, which allowed the optimization of the development stage. The pellets produced and used in biphasic formulations were evaluated for physical and chemical characteristics and presented acceptable results. The immediate fraction obtained showed the complete release in 30 min while the others kept the release of the drug for 24 h. This study showed that the combination of beads with different releasing characteristics allowed to obtain different release profiles, which can be modulated according to the pathological needs, especially with regard to circadian diseases that suffer alterations throughout the day.

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Published
2018-12-20
How to Cite
Martins, S., Müller, V., Galan, V., Souza, F., Andreazza, I., & Rosa, M. (2018). Development and evaluation of multiparticulate biphasic system for the treatment of circadian diseases. Brazilian Journal of Pharmaceutical Sciences, 54(4), e17167. https://doi.org/10.1590/s2175-97902018000417167
Section
Articles