Pharmacokinetics of oleracimine in rats by ultra-high-performance liquid chromatography

  • Gonglin Qu National Institute for Radiological Protection
  • Liang Xu Liaoning University of Traditional Chinese Medicine, School of Pharmacy
  • Wenjie Zhang
  • Xixiang Ying Liaoning University of Traditional Chinese Medicine, School of Pharmacy
Keywords: Portulaca oleracea L./Oleracimine, Ultra-High-Performance Liquid Chromatography/Rat plasma, Pharmacokinetics

Abstract

The novel alkaloid, oleracimine, presented remarkable anti-inflammatory bioactivity, and therefore, its pharmacokinetics was investigated in rat plasma after intravenous and oral administration by using a rapid ultra-high-performance liquid chromatography (UHPLC) method with UV detection at 270 nm. The analysis was performed on a shim-pack ODS column (75 mm×2 mm, 1.6 µm particle size, Shimadzu, Japan) column using isocratic elution with a mobile phase consisting of methanol-water (62:38, v/v) within 3 min. The results indicated that oleracimine was rapidly distributed with Tmax for 11.7 min after oral administration, which presented the double-peak phenomenon in the pharmacokinetic profile with a higher oral absolute bioavailability of 55.1% ± 7.83%.

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Published
2018-12-20
How to Cite
Qu, G., Xu, L., Zhang, W., & Ying, X. (2018). Pharmacokinetics of oleracimine in rats by ultra-high-performance liquid chromatography. Brazilian Journal of Pharmaceutical Sciences, 54(4), e17242. https://doi.org/10.1590/s2175-97902018000417242
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Articles