Biomarker responses (serum biochemistry) in pregnant female wistar rats and histopathology of their neonates exposed prenatally to pesticides

  • Jyoti Upadhyay Kumaun University, Department of Pharmaceutical Sciences
  • Mahendra Rana Kumaun University, Department of Pharmaceutical Sciences
  • Satpal Singh Bisht Kumaun University, Department of Zoology
  • Amita Rana Kumaun University, Department of Pharmaceutical Sciences
  • Sumit Durgapal Kumaun University, Department of Pharmaceutical Sciences
  • Vijay Juyal Kumaun University, Department of Pharmaceutical Sciences
Keywords: Glyphosate, Carbendazim, Biomarker responses, Biomarkers/ analysis, Pesticide exposure/ histopathology, Newborn/ histopathology, Herbicides/ toxicity

Abstract

Experiments were conducted to investigate the effects on health of pregnant female rats exposed to pesticides glyphosate and carbendazim. Glyphosate is used as herbicide and carbendazim as a fungicide; all are commercially available readily for various agricultural and domestic purposes. The hypothesis tested in this investigation is that pesticide exposure during pregnancy causes changes in biomarker responses like serum glucose level, total protein, total cholesterol, triglycerides, SGOT, SGPT, and billirubin level. Significant changes were observed in all above biomarker responses, when compared with the reference. Histopathology of skin and kidney of rat neonates showed marked damage. Degenerative changes and vacuolization with eroded capsule were observed in kidney sample and thinning of epidermis in skin sample was seen in pesticides exposed neonates of rats. The serum biochemistry and histopathological findings are valuable markers for observing the changes caused by pesticide exposure.

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Published
2019-08-07
How to Cite
Upadhyay, J., Rana, M., Bisht, S., Rana, A., Durgapal, S., & Juyal, V. (2019). Biomarker responses (serum biochemistry) in pregnant female wistar rats and histopathology of their neonates exposed prenatally to pesticides. Brazilian Journal of Pharmaceutical Sciences, 55, e18194. https://doi.org/10.1590/s2175-97902019000118194
Section
Articles