Protective effects of salidroside on chronic heart failure in rats and the underlying mechanisms

  • Chengxi Zhang Sun Yat-Sen University, the Third Affiliated Hospital https://orcid.org/0000-0003-2419-9467
  • Sinian Pan Sun Yat-Sen University, the Third Affiliated Hospital
  • Leile Tang Sun Yat-Sen University, the Third Affiliated Hospital
  • Yesheng Ling Sun Yat-Sen University, the Third Affiliated Hospital
  • Xiaojing Zhou The First People’s Hospital of Xinjiang Kashi Area
  • Wei Feng The First People’s Hospital of Xinjiang Kashi Area
Keywords: Salidroside/protective effects, Chronic heart failure

Abstract

The present study aimed to investigate the protective effects of salidroside on chronic heart failure (CHF) in rats and to explore the underlying mechanisms. One hundred SD rats were randomly divided into sham-operated, model, and low-, medium- and high-dose salidroside groups. The CHF model was established in later 4 groups. The later 3 groups were intragastrically administrated with 6, 12 and 24 mg/kg salidroside, respectively, once a day, for continuous 4 weeks. Finally, the serum levels of brain natriuretic peptide (BNP) and interleukin 6 (IL-6), cardiac function indexes, and expression levels of myocardial cysteinyl aspartate-specific proteinase (Caspase)-3, Caspase-9, matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) protein were determined. Results showed that, after treatment, compared with model group, in high-dose salidroside group the heart function indexes were significantly improved (P < 0.05), the serum levels of BNP and IL-6 were significantly decreased (P < 0.05), the expression levels of myocardial Caspase-3, Caspase-9 and MMP-1 protein were significantly decreased (P < 0.05), and the expression level of TIMP-1 protein was significantly increased (P < 0.05). In conclusion, salidroside has obvious protective effects on CHF in rats. The mechanisms may be related to its regulation of cardiomyocyte apoptosis and ventricular remodelingregulation related protein expressions.

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Published
2019-11-29
How to Cite
Zhang, C., Pan, S., Tang, L., Ling, Y., Zhou, X., & Feng, W. (2019). Protective effects of salidroside on chronic heart failure in rats and the underlying mechanisms. Brazilian Journal of Pharmaceutical Sciences, 55, e18222. https://doi.org/10.1590/s2175-97902019000118222
Section
Articles