Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery

  • Shiva Taghe Kermanshah University of Medical Sciences, Student Research Committee School of Pharmacy
  • Shahla Mirzaeei Kermanshah University of Medical Sciences, School of Pharmacy https://orcid.org/0000-0002-1132-3150
Keywords: Ocular drug delivery, Nanoparticles, Corneal penetration, Ofloxacin, Chitosan

Abstract

The efficacy of conventional ocular formulations is limited by poor corneal retention and permeation, resulting in low ocular bioavailability. Mucoadhesive chitosan (CS)/ tripolyphosphatesodium (TPP) and chitosan (CS)/ tripolyphosphatesodium (TPP)-alginate (ALG) nanoparticles were investigated for the prolonged topical ophthalmic delivery of ofloxacin. A modified ionotropic gelation method was used to produce ofloxacin-loaded nanoreservoir systems. The ofloxacin-loaded CS/TPP and CS/TPP-ALG nanoparticles were characterized for particle size, morphology, zeta potential, encapsulation efficiency, subsequent release and corneal penetration study. The designed nanoparticles have a particle size from 113.8 nm to 509 nm and zeta potential from 16.2 mV to 40.3 mV and encapsulation efficiency values ranging from 19.7% to 33.1%. Nanoparticles revealed a release during the first hours, followed by a more gradual drug release. The ofloxacin-loading CS/TPP or CS/TPP-ALG NPs developed are pronounced penetration enhancing effect as compared to OFX solution (5-6.5 times). Thus, these nanoparticles have a strong potential for ocular drug delivery.

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Published
2019-11-29
How to Cite
Taghe, S., & Mirzaeei, S. (2019). Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery. Brazilian Journal of Pharmaceutical Sciences, 55, e17105. https://doi.org/10.1590/s2175-97902019000117105
Section
Articles