Metabolic dysregulation in early onset psychiatric disorder before and after exposure to antipsychotic drugs

  • Rehmat Shah University of Peshawar, Department of Pharmacy https://orcid.org/0000-0001-5659-3456
  • Fazal Subhan University of Peshawar, Department of Pharmacy
  • Syed Muhammad Sultan Medical Teaching Institution
  • Matiul Haq Institute of Radiotherapy and Nuclear Medicine
  • Hussain Ahmad Medical teaching institution
  • Qasim Riaz Khan Medical Teaching Institution
  • Gowhar Ali University of Peshawar, Department of Pharmacy
  • Sami Ullah University of Peshawar, Department of Pharmacy
  • Ihsan Ullah University of Swabi, Department of Pharmacy
Keywords: Olanzapine, Quetiapine, Risperidone, Antipsychotics, Pancreas, Insulin

Abstract

Antipsychotic Drugs (APDs) are being widely prescribed to treat various disorders, including schizophrenia and bipolar disorder; however, abnormal glucose metabolism and weight gain have been reported with Atypical Anti-Psychotic drugs (AAPDs) that can lead to insulin-resistance and type 2 diabetes mellitus. The study was designed to assess various biochemical parameters including insulin and blood sugar before and after exposure to APDs in order to exclude the involvement of psychiatric disorders and certain other factors in metabolic dysregulations. Fifty seven APDs-naïve patients with first episode psychosis were divided into six groups who received olanzapine, quetiapine, risperidone, aripiprazole, haloperidol or combination of olanzapine with escitalopram and haloperidol. The serum samples were taken before the intake of the first dose and then on follow-up. Decrease in the level of elevated insulin and glucose was observed post-treatment in some patients, while others were observed whose insulin and glucose levels increased post-treatment, yet some patients did not show any disturbance in the insulin and glucose levels. It is concluded that psychiatric disorders by itself, narcotics, cigarette smoking and use of oral snuff may be also be implicated in metabolic dysregulations. The effects of APDs on insulin and glucose in healthy volunteers might be different than in patients with psychiatric disorders.

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Published
2019-12-03
How to Cite
Shah, R., Subhan, F., Sultan, S., Haq, M., Ahmad, H., Khan, Q., Ali, G., Ullah, S., & Ullah, I. (2019). Metabolic dysregulation in early onset psychiatric disorder before and after exposure to antipsychotic drugs. Brazilian Journal of Pharmaceutical Sciences, 55, e17825. https://doi.org/10.1590/s2175-97902019000117825
Section
Articles