Effects of gallic acid and physical exercise on passive avoidance memory in male rat

  • Azadeh Salehi Islamic Azad University, Izeh Branch
  • Zahra Rabiei Shahrekord University of Medical Sciences, Basic Health Sciences Institute
  • Mahbubeh Setorki Islamic Azad University, Izeh Branch https://orcid.org/0000-0001-6983-9929
Keywords: Gallic Acid/adverse effects, Learning/drug effects, Memory/drug effects, Physical Exercise/ physiology, MDA, Avoidance Learning/drug effects, Exercise/physiology, Rats/physiology, Malondialdehyde/analysis

Abstract

Learning and memory play main roles in daily life of human, and memory represents the basis of all trainings and learning. The aim of the current study is to investigate the effects of gallic acid and physical exercise on the levels of passive avoidance memory in rat. In this experimental study, 46 rats weighing 200-300 g were randomLy divided to six groups of eight each: including control group, groups treated with 10 and 20 mg/kg gallic acid, group undergoing physical exercise alone, and groups both undergoing physical exercise and treated with 10 and 20 mg/kg gallic acid. The interventions continued for 10 days. After the intervention, passive avoidance memory was measured by shuttle box, blood samples were taken, and serum and brain antioxidant capacity and malondialdehyde (MDA) levels were measured. Secondary latency in shuttle box significantly increased in groups undergoing treadmill exercise and undergoing treadmill exercise + treating 10 and 20 mg/kg gallic acid. In groups treated with 10 and 20 mg/kg gallic acid alone, secondary latency increased significantly. Results confirmed the effects of gallic acid and physical exercise, either alone or combined, in improving memory.

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Published
2019-12-06
How to Cite
Salehi, A., Rabiei, Z., & Setorki, M. (2019). Effects of gallic acid and physical exercise on passive avoidance memory in male rat. Brazilian Journal of Pharmaceutical Sciences, 55, e18261. https://doi.org/10.1590/s2175-97902019000218261
Section
Articles