Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects

  • Rabeb Tej Unité de Physiologie et de Biochimie de la Réponse des Plantes aux Contraintes Abiotiques, Faculté des Sciences de Tunis
  • Amel Hamdi Unité de Physiologie et de Biochimie de la Réponse des Plantes aux Contraintes Abiotiques, Faculté des Sciences de Tunis
  • Raja Serairi Beji Center of Biotechnology of the Technopole Borj-Cedria
  • Wissem Aidi Wanne Center of Biotechnology of the Technopole Borj-Cedria https://orcid.org/0000-0003-3134-0457
  • Iness Bettaieb Rebey Center of Biotechnology of the Technopole Borj-Cedria
  • Samia Oueslati Center of Biotechnology of the Technopole Borj-Cedria
  • Riadh Ksouri Center of Biotechnology of the Technopole Borj-Cedria
  • Moufida Saidani Tounsi Center of Biotechnology of the Technopole Borj-Cedria
  • Mokhtar Lachaal Unité de Physiologie et de Biochimie de la Réponse des Plantes aux Contraintes Abiotiques, Faculté des Sciences de Tunis
  • Najoua Karray Bouraoui Unité de Physiologie et de Biochimie de la Réponse des Plantes aux Contraintes Abiotiques, Faculté des Sciences de Tunis
Keywords: Lycium europaeum/extract/antihyperglycemia, Lycium europaeum/extract/antioxidant activity, Lycium europaeum/extract/antihyperlipidemia

Abstract

The purpose of the present investigation is to assess, for the first time, the antidiabetic, antihyperlipidemic and antioxidant activities of Lycium europaeum extract in alloxan-induced diabetic rats. Diabetes was induced in adult male Wistar rats via a single subcutaneous alloxan injection (120 mg/kg). Lycium europaeum aqueous extract was orally administered at a dose of 20 mg/kg for 28 consecutive days. Serum concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) were assayed at the end of the experimental period in all investigated groups. Antioxidant enzymes such as glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) were sought in the serum and pancreas. Lycium europaeum extract significantly increased HDL-C and reduced blood glucose, TC, LDL-C and TG as compared to the alloxan-control group. Lycium europaeum extract was also efficient in reducing oxidative stress in diabetic rats by increasing SOD, CAT and GPx activities both in the pancreas and the plasma of the animals. Moreover, Lycium europaeum extract contained considerable levels of polyphenols and flavonoids. It also exhibited an important antioxidant capacity and a remarkable ability to quench DPPH radicals and reduce irons. The obtained results highlight potentially relevant health beneficial effects of Lycium europaeum extract, reversing hyperglycemic, hyperlipidemic and oxidative stress effects in rats with alloxan-induced diabetes. Therefore, it may be considered as a promising alternative or complementary agent to diabetes treatment.

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Published
2019-12-06
How to Cite
Tej, R., Hamdi, A., Beji, R., Wanne, W., Rebey, I., Oueslati, S., Ksouri, R., Tounsi, M., Lachaal, M., & Bouraoui, N. (2019). Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects. Brazilian Journal of Pharmaceutical Sciences, 55, e18064. https://doi.org/10.1590/s2175-97902019000118064
Section
Articles