Case report and immunohistochemical study of a malignant peripheral nerve sheath tumor in a dog

  • Thaís de Almeida Moreira Universidade Federal de Uberlândia, Faculdade de Medicina Veterinária
  • Leandro Willian Borges Universidade Federal de Uberlândia, Faculdade de Medicina Veterinária
  • Talita Lopes Serra Universidade Federal de Minas Gerais, Faculdade de Medicina Veterinária
  • Diego Petrocino Caetano Universidade Federal de Uberlândia, Faculdade de Medicina Veterinária
  • Marcelo Carrijo da Costa Universidade Federal de Uberlândia, Faculdade de Medicina Veterinária
  • Alessandra Aparecida Medeiros-Ronchi Universidade Federal de Uberlândia, Faculdade de Medicina Veterinária
Keywords: Neoplasm, Pelvic member, Canine, Markers

Abstract

Malignant peripheral nerve sheath tumor is rare and rarely reported in dogs. The term neurofibroma/sarcoma is classically used when the tumor is composed of Schawann and perineural cells. This work describes the clinical, histopathological, and immunohistochemical case of a subcutaneous malignant peripheral nerve sheath tumor, most likely a malignant neurofibroma located in the pelvic member of a Rottweiler dog. Histopathological features and immunohistochemical analysis corroborated the diagnosis, showing positivity for S-100 protein, vimentin, and CD57, and was useful to distinguish this type of neoplasm from other malignancies of similar morphologies.

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Author Biography

Thaís de Almeida Moreira, Universidade Federal de Uberlândia, Faculdade de Medicina Veterinária
Mestranda em Ciências Veterinárias, linha de pesquisa em clínica médica e investigação etiológica. Possui especialização (residência médica) em patologia animal.
Published
2017-12-31
How to Cite
Moreira, T., Borges, L. W., Serra, T., Caetano, D., Costa, M., & Medeiros-Ronchi, A. A. (2017). Case report and immunohistochemical study of a malignant peripheral nerve sheath tumor in a dog. Brazilian Journal of Veterinary Research and Animal Science, 54(4), 420-424. https://doi.org/10.11606/issn.1678-4456.bjvras.2017.132447