Antimicrobial resistance in bacteria isolated from pigs with respiratory clinical signs in Brazil

  • Maysa Serpa Universidade Federal de Lavras, Departamento de Medicina Veterinária https://orcid.org/0000-0002-1831-2753
  • Juliana Amália Fonte Bôa do Nascimento Universidade Federal de Minas Gerais, Escola de Veterinária, Departamento de Medicina Veterinária Preventiva
  • Mirian Fátima Alves Universidade Federal de Lavras, Departamento de Medicina Veterinária
  • Maria Isabel Maldonado Coelho Guedes Universidade Federal de Minas Gerais, Escola de Veterinária, Departamento de Medicina Veterinária Preventiva https://orcid.org/0000-0002-6734-0216
  • Adrienny Trindade Reis Instituto de Pesquisas Veterinárias Especializadas
  • Marcos Bryan Heinemann Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Medicina Veterinária Preventiva e Saúde Animal https://orcid.org/0000-0001-6444-9788
  • Andrey Pereira Lage Universidade Federal de Minas Gerais, Escola de Veterinária, Departamento de Medicina Veterinária Preventiva https://orcid.org/0000-0002-9325-5728
  • Zélia Inês Portela Lobato Universidade Federal de Minas Gerais, Escola de Veterinária, Departamento de Medicina Veterinária Preventiva https://orcid.org/0000-0002-9399-3691
  • Elaine Maria Seles Dorneles Universidade Federal de Lavras, Departamento de Medicina Veterinária https://orcid.org/0000-0002-2753-1296
Keywords: Multidrug resistance, Streptococcus suis, Pasteurella multocida, Haemophilus parasuis, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica

Abstract

Antimicrobial resistance is a current and important issue to public health, and it is usually associated with the indiscriminate use of antimicrobials in animal production. This study aimed to evaluate the antimicrobial susceptibility profile in bacterial isolates from pigs with clinical respiratory signs in Brazil. One hundred sixty bacterial strains isolated from pigs from 51 pig farms in Brazil were studied. In vitro disk-diffusion method was employed using 14 antimicrobial agents: amoxicillin, penicillin, ceftiofur, ciprofloxacin, enrofloxacin, chlortetracycline, doxycycline, oxytetracycline, tetracycline, erythromycin, tilmicosin, florfenicol, lincomycin, and sulfadiazine/trimethoprim. The majority of isolates were resistant to at least one antimicrobial agent (98.75%; 158/160), while 31.25% (50/160) of the strains were multidrug resistant. Streptococcus suis and Bordetella bronchiseptica were the pathogens that showed higher resistance levels. Haemophilus parasuis showed high resistance levels to sulfadiazine/trimethoprim (9/18=50%). We observed that isolates from the midwestern and southern regions exhibited four times greater chance of being multidrug resistant than the isolates from the southeastern region studied. Overall, the results of the present study showed a great level of resistance to lincomycin, erythromycin, sulfadiazine/trimethoprim, and tetracycline among bacterial respiratory pathogens isolated from pigs in Brazil. The high levels of antimicrobial resistance in swine respiratory bacterial pathogens highlight the need for the proper use of antimicrobials in Brazilian pig farms.

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Published
2020-05-15
How to Cite
Serpa, M., Nascimento, J. A., Alves, M. F., Guedes, M. I., Reis, A., Heinemann, M. B., Lage, A., Lobato, Z. I., & Dorneles, E. (2020). Antimicrobial resistance in bacteria isolated from pigs with respiratory clinical signs in Brazil. Brazilian Journal of Veterinary Research and Animal Science, 57(1), e160956. https://doi.org/10.11606/issn.1678-4456.bjvras.2020.160956
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