Clinical variability in the determination of oral toxic dosis in the experimental intoxication with sodium fluoroacetate in cats

  • Rita de Cássia Collicchio-Zuanaze Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Clínica Veterinária, Botucatu, SP
  • Michiko Sakate Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Clínica Veterinária, Botucatu, SP
  • Adalberto José Crocci Universidade Estadual Paulista, Instituto de Biociências, Departamento de Bioestatística, Botucatu, SP
Keywords: Sodium monofluoroacetate, Rodenticide, Intoxication, Clinical variability, Oral toxic dosis

Abstract

The sodium monofluoroacetate (FAC) or compound 1080 is a potent rodenticide used for a rodents and vertebrate pest control. It was prohibited in many countries because of its high toxicity, but in Brazil exist evidences of ilegal use causing the intoxication in children and domestic animals. The fluoroacetate metabolite, fluorocitric acid, blocks body energy production by inhibit the Krebs cycle, resulting in neurological and cardiacs signs. In the present study, four group of oral toxic dosis of the FAC were compared in cats. The best oral toxic dose for clinical signs presentation, without cause acute lethality, was 0,45mg/kg. The clinical variability was dosis dependent and its intensity , in crescent order, was: light signs (dose 1: 0,3mg/kg), light to moderate (dose 2: 0,4mg/kg), moderate to severe (dose 3: 0,45mg/kg) and severe (dose 4: 0,5mg/kg). There was individual clinical variability between animals that received the same oral toxic dose.

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Published
2006-02-01
How to Cite
Collicchio-Zuanaze, R., Sakate, M., & Crocci, A. (2006). Clinical variability in the determination of oral toxic dosis in the experimental intoxication with sodium fluoroacetate in cats. Brazilian Journal of Veterinary Research and Animal Science, 43(1), 117-124. https://doi.org/10.11606/issn.1678-4456.bjvras.2006.26526
Section
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