Histological and immunohistochemical study of the central nervous system of dogs naturally infected by Leishmania (Leishmania) chagasi

  • Fabiana Augusta Ikeda Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Vaterinárias, Jaboticabal, SP
  • Márcia Dalastra Laurenti Universidade de São Paulo, Faculdade de Medicina, Departamento de Patologia, São Paulo, SP
  • Carlos Eduardo Corbett Universidade de São Paulo, Faculdade de Medicina, Departamento de Patologia, São Paulo, SP
  • Mary Marcondes Feitosa Universidade Estadual Paulista, Departamento de Clínica, Cirurgia e Reprodução Animal, Araçatuba, SP
  • Gisela Fabrino Machado Universidade Estadual Paulista, Departamento de Clínica, Cirurgia e Reprodução Animal, Araçatuba, SP
  • Silvia Helena Venturoli Perri Universidade Estadual Paulista, Departamento de Clínica, Cirurgia e Reprodução Animal, Araçatuba, SP
Keywords: Leishmania chagasi, Dogs, Histopathology, Immunohistochemistry, Central nervous system

Abstract

The present study aimed to characterize the histopathological alterations and to detect, by immunohistochemistry, the presence of amastigote forms of Leishmania in CNS tissue of dogs with and without neurological clinical signs of the disease. Two groups of animals were used: the first was composed of 18 dogs with visceral leishmaniasis without clinical evidence of neurological involvement, and the second, composed of 21 dogs with visceral leishmaniasis and neurological symptoms. The most frequent histopathological alterations found in the CNS of dogs of both groups were neuronal degeneration with neuronophagia, gliosis, leptomeningitis, vascular congestion, presence of perivascular lymphoplasmacytic infiltrate and areas of focal microhemorrhage. Antigen labeling for whole forms of Leishmania amastigotes was not observed in any fragment of the CNS of the dogs of either groups; however, most of them presented labeling of blood vessels walls, which suggests the presence of circulating parasite antigens.

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Published
2007-02-01
How to Cite
Ikeda, F., Laurenti, M., Corbett, C., Feitosa, M., Machado, G., & Perri, S. (2007). Histological and immunohistochemical study of the central nervous system of dogs naturally infected by Leishmania (Leishmania) chagasi. Brazilian Journal of Veterinary Research and Animal Science, 44(1), 5-11. https://doi.org/10.11606/issn.1678-4456.bjvras.2007.26653
Section
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