Effect of cyclosporin A on renal functions of normal Golden Retriever dogs or Golden Retriever with muscular dystrophy

  • Adriana Caroprezo Morini Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Maria Angélica Miglino Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Marileda Bonafim Carvalho Universidade Estadual de São Paulo, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP
  • Daniele dos Santos Martins Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Carlos Eduardo Ambrósio Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Carla Fabiana Casagrande Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Alida Abatemarco Catelli Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Ana Paula Souza Universidade Estadual de São Paulo, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP
  • Martha Maria Circhia Pinto Luppi Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Thaís Peixoto Gaiad Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Mayana Zatz Universidade de São Paulo, Instituto de Biologia, Centro de Estudos do Genoma Humano, São Paulo, SP
Keywords: Immunosuppression, Nefrototoxicity

Abstract

The muscular dystrophy of Golden Retriever is a degenerative miopaty caused by the absence of dystrophy and it is genetically homologue of the Duchenne muscular dystrophy in humans, so, these dogs are considerably experimental models for studies on cellular therapy. Their successful depends of the adequate immunosuppression. Cyclosporin A is indicated for that and the monitoring of blood concentration and adverse effects are essential to viabilise the therapy. It was studied GRMD dogs, and normal dogs from the same breed, submitted for therapy with CsA, associated, on GRMD, of cell transplantation. It was evaluated the possible effects of the drug on renal functions. It has been considerate the clinic manifestations, urinalisis, testis of glomerular function and blood concentrations of urea, cretinine, sodium and potassium. In our results we found a discrete increase of blood urea on booth groups; increased levels of urine's cylinders and protein and also increase of urinary density on GRMD group. CsA therapy could make acute lesions on renal tubules, especially on GRMD. These dogs also have different reactions than normal dogs on relation of ions homeostasis and renal function. However, earlier diagnosis and adequate treatment could prevent the development of renal diseases.

Downloads

Download data is not yet available.
Published
2008-10-01
How to Cite
Morini, A., Miglino, M., Carvalho, M., Martins, D., Ambrósio, C., Casagrande, C., Catelli, A., Souza, A., Luppi, M., Gaiad, T., & Zatz, M. (2008). Effect of cyclosporin A on renal functions of normal Golden Retriever dogs or Golden Retriever with muscular dystrophy. Brazilian Journal of Veterinary Research and Animal Science, 45(5), 371-378. https://doi.org/10.11606/issn.1678-4456.bjvras.2008.26678
Section
UNDEFINIED

Most read articles by the same author(s)

1 2 3 4 5 > >>