Analyses of dosages and blood concentration of cyclosporin A on norrmal Golden Retriever dogs or Golden Retriever with muscular dystrophy

  • Adriana Caroprezo Morini Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Maria Angélica Miglino Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Marileda Bonafim Carvalho Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP
  • Daniele dos Santos Martins Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Carlos Eduardo Ambrósio Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Lílian Jesus de Oliveira Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Alida Abatemarco Catelli Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Ana Paula Souza Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP
  • José Roberto Kfoury Junior Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Martha Maria Circhia Pinto Luppi Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Thaís Peixoto Gaiad Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Mayana Zatz Universidade de São Paulo, Instituto de Biologia, Centro de Estudos do Genoma Humano, São Paulo, SP
Keywords: Immunosuppression, Golden Retriever muscular dystrophy, Blood concentration, Fluorescence polarization immunoassay (FPIA)

Abstract

The muscular dystrophy of Golden Retriever (GRMD) is a degenerative miopaty caused by the absence of dystrophy and it is genetically homologue of the Duchenne muscular dystrophy in humans, so, these dogs are considerably experimental models for studies on cellular therapy. Their successful depends of the adequate immunosuppression. Cyclosporin A (CsA) is indicated for that and the monitoring of the blood concentration and adverse effects are essential to viabilise the therapy. It was studied GRMD dogs, and normal dogs from the same breed, submitted for therapy with CsA, associated, on GRMD, of cell transplantation. It was evaluated blood concentration of the drug, between two or tree days using the method of FPIA. In our results we found that the CsA blood concentrations oscillated too much on six than eight of our animals. We concluded that the doses varieties individually and the correct dosage as to important as the evaluation of the blood concentration of the drug and became viable for cell therapy.

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Published
2008-04-01
How to Cite
Morini, A., Miglino, M., Carvalho, M., Martins, D., Ambrósio, C., Oliveira, L., Catelli, A., Souza, A., Kfoury Junior, J., Luppi, M., Gaiad, T., & Zatz, M. (2008). Analyses of dosages and blood concentration of cyclosporin A on norrmal Golden Retriever dogs or Golden Retriever with muscular dystrophy. Brazilian Journal of Veterinary Research and Animal Science, 45(2), 131-137. https://doi.org/10.11606/issn.1678-4456.bjvras.2008.26710
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