Embryotoxic effects of prenatal treatment with Ipomoea carnea aqueous fraction in rats

  • Rosana Zoriki Hosomi Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Helenice de Souza Spinosa Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Silvana Lima Górniak Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Soraya Ferreira Habr Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Sandra Witaker Penteado Universidade Paulista, São Paulo, SP
  • Franci Mary Fantinato Varoli Instituto Presbiteriano Mackenzie, São Paulo, SP
  • Maria Martha Bernardi Instituto Presbiteriano Mackenzie, São Paulo, SP
Keywords: Ipomoea, Teratogens, Prenatal care

Abstract

The embryotoxic effects of prenatal daily exposure to 0.0, 0.7, 3.0 or 15.0 mg/kg of the aqueous extract (AQE) from Ipomoea carnea (I. carnea) dried leaves on gestational days 521 were studied in rats. Maternal reproductive performance, skeletal and visceral abnormalities, and malformations were evaluated. Moreover, anatomopathological findings in dams following the treatment were recorded. Regarding the dams, our results show that body weight, weight gain, food and water consumption, and reproductive performance were all unaffected by exposure to the different doses of the AQE. Nonetheless, dams treated with AQE presented a dose-dependent cytoplasmic vacuolation in the liver, kidneys, thyroid and adrenal glands. Fetal examination did not show external abnormalities or malformations. Evidences of several skeletal and visceral abnormalities were found, particularly after the higher dose of AQE. A reduced ossification centers were also detected. The present data show that prenatal ingestion of the I. carnea AQE in rats induces embryotoxicity. These effects are attributed to an active principle from I. carnea acting on maternal homeostasis, or directly in the conception.

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Published
2008-02-01
How to Cite
Hosomi, R., Spinosa, H., Górniak, S., Habr, S., Penteado, S., Varoli, F., & Bernardi, M. (2008). Embryotoxic effects of prenatal treatment with Ipomoea carnea aqueous fraction in rats. Brazilian Journal of Veterinary Research and Animal Science, 45(1), 67-75. https://doi.org/10.11606/issn.1678-4456.bjvras.2008.26722
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