Longitudinal study of bone mineral density in healthy, carrier, and affected dogs by Golden Retriever Muscular Dystrophy

  • Robson Fortes Giglio University of Florida, College of Veterinary Medicine, Diagnostic Imaging Intern, Florida, USA
  • Cássio Ricardo Auada Ferrigno Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Franklin de Almeida Sterman Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Ana Carolina Brandão de Campos Fonseca Pinto Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Júlio César de Carvalho Balieiro Universidade de São Paulo, Faculdade de Zootecnia e Engenharia de Alimentos, Pirassununga, SP
  • Carlos Eduardo Ambrosio Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Daniele dos Santos Martins Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Ana Rita Lima Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Angelica Paula Grando Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Maria Angélica Miglino Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Mayana Zatz Universidade de São Paulo, Instituto de Biociências, São Paulo, SP
Keywords: Bone densitometry, Radiology, Dogs, Golden Retriever dogs, Muscular dystrophy

Abstract

The Golden Retriever Muscular Dystrophy (GRMD) is considered the most appropriate model of the Duchenne Muscular Dystrophy (DMD) in humans. Decrease in Bone Mineral Density (DMO) has been recognized in ambulatory and non-ambulatory boys with DMD. The Radiographic Optical Densitometry is a method to measure the bone mineral content. It was performed radiographing the proximal right tibia next to an aluminum stepwedge. Fifteen Golden Retriever dogs had been used, divided in three groups: Five healthy, five carriers and five affected by GRMD, monthly radiographed, from 3 to 9 months-old. These radiographies were analyzed by image processing software (ImageLab, Softium®). The proximal epiphysis had higher bone mineral density, followed for the metaphysic and diaphysis, respectively. All regions followed has influence the body weight. There was an increase of the bone mineral density in all regions of the three groups. The proximal metaphysis was thought to be the better region to evaluate the bone mineral density because had less correlation and influence of the body weight, and, also, had different significant values to differentiate the groups earlier than the other regions. The potential diagnostic of this densitometric method in GRMD was considered low, however it demonstrated to have great potential in the clinical recheck of this patients due to the high sensitivity for detection of changes in the bone mineral density.

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Published
2009-10-01
How to Cite
Giglio, R., Ferrigno, C., Sterman, F., Pinto, A., Balieiro, J., Ambrosio, C., Martins, D., Lima, A., Grando, A., Miglino, M., & Zatz, M. (2009). Longitudinal study of bone mineral density in healthy, carrier, and affected dogs by Golden Retriever Muscular Dystrophy. Brazilian Journal of Veterinary Research and Animal Science, 46(5), 347-354. https://doi.org/10.11606/issn.1678-4456.bjvras.2009.26783
Section
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