Evaluation of bone and liver alkaline phosphatase in cats with induced thyrotoxicosis

  • Fabiano Séllos Costa Universidade Federal do Espírito Santo, Centro de Ciências Agrárias, Departamento de Medicina Veterinária, Alegre, ES
  • Mauro José Lahm Cardoso Universidade Estadual do Paraná, Fundação Faculdades Luiz Meneghel, Bandeirantes, PR
  • Lucy Marie Ribeiro Muniz Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Reprodução Animal e Radiologia Veterinária, Botucatu, SP
  • Luiz Carlos Vulcano Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Reprodução Animal e Radiologia Veterinária, Botucatu, SP
  • Paulo Roberto Rodrigues Ramos Universidade Estadual Paulista, Instituto de Biociências, Departamento de Biofísica, Botucatu, SP
  • Luís Antonio Justulin Junior Universidade Estadual de Campinas, Instituto de Biologia, Departamento de Biologia Celular, Campinas, SP
  • Sérgio Luís Felisbino Universidade Estadual Paulista, Instituto de Biociências, Departamento de Morfologia, Botucatu, SP
  • Warley Gomes dos Santos Universidade Federal do Espírito Santo, Centro de Ciências Agrárias, Departamento de Medicina Veterinária, Alegre, ES
Keywords: Alkaline phosphatase, Isoenzyme, Hyperthyroidism, Cat

Abstract

Thyrotoxicosis, characterized by excessive serum levels of thyroid hormones, can cause serious effects in bone metabolism, elevating the total alkaline phosphatase, which is a frequent laboratorial alteration observed in feline hyperthyroidism. A rise in total serum levels of alkaline phosphatase can be caused by different isoenzymes, and in human hyperthyroidism, bone and hepatic isoenzymes are commonly increased. After serum biochemical evaluation of eight cats with induced thyrotoxicosis and associated elevation of alkaline phosphatase, the present paper shows a significant elevation of bone isoenzyme serum levels when compared with hepatic isoenzyme. It was possible to conclude that bone metabolism alterations were the main responsible for the increase of serum alkaline phosphatase in cats with induced thyrotoxicosis.

Downloads

Download data is not yet available.
Published
2009-10-01
How to Cite
Costa, F., Cardoso, M., Muniz, L., Vulcano, L., Ramos, P., Justulin Junior, L., Felisbino, S., & Santos, W. (2009). Evaluation of bone and liver alkaline phosphatase in cats with induced thyrotoxicosis. Brazilian Journal of Veterinary Research and Animal Science, 46(5), 387-394. https://doi.org/10.11606/issn.1678-4456.bjvras.2009.26788
Section
UNDEFINIED