Pathology of bovine neonates generated by somatic cell nuclear transfer: Cloning

  • Caio Rodrigues dos Santos Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, São Paulo, SP
  • Fabrizio Grandi Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, São Paulo, SP
  • Maria Angélica Miglino Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Flávio Vieira Meirelles Universidade de São Paulo, Faculdade de Zootecnia e Engenharia de Alimentos, Pirassununga, SP
  • Paulo César Maiorka Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, São Paulo, SP
Keywords: Neonates bovine, Cloned, Pathology, Nuclear transfer

Abstract

The death mechanisms in cloned animals are not well elucidated. There are few cases describing organ malformation, size and weight alterations in these animals. Pathologic studies are necessary to understand the high level of unsuccessful results using the NTSC (nuclear transfer somatic cell) technique. The present study was carried out to describe alterations present in a group of animals generated by NTSC technique that deceased between 0 to 19 days of life, using anatomopathologic examination. This experiment was conducted at Tambaú Farm in São Paulo State between years 2004 and 2008. Initially there were twenty one Nelore breed Bos indicus animals, but 11 of them deceased and ten survived and showed satisfactory clinical evolution in perinatal period. Animals necropsies and histopathologic analyses where performed. The results revealed a high prevalence of cardiopulmonary alterations, which were predominantly lung hypertension and hemodynamic profile changes, revealed by histopathologic analyses.

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Published
2010-12-01
How to Cite
Santos, C., Grandi, F., Miglino, M., Meirelles, F., & Maiorka, P. (2010). Pathology of bovine neonates generated by somatic cell nuclear transfer: Cloning. Brazilian Journal of Veterinary Research and Animal Science, 47(6), 447-453. https://doi.org/10.11606/issn.1678-4456.bjvras.2010.26806
Section
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