Plasma levels, pharmacokinetics and dosage regimen of intravenously administered gatifloxacin in buffalo calves (Bubalus bubalis) on coadministration with meloxicam

Authors

  • Vinod Kumar Dumka Guru Angad Dev Veterinary and Animal Sciences University, College of Veterinary Science, Department of Pharmacology and Toxicology, Ludhiana
  • Harpal Singh Sandhu Guru Angad Dev Veterinary and Animal Sciences University, College of Veterinary Science, Department of Pharmacology and Toxicology, Ludhiana
  • Neetu Rajput Guru Angad Dev Veterinary and Animal Sciences University, College of Veterinary Science, Department of Pharmacology and Toxicology, Ludhiana

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.2010.26808

Keywords:

Buffalo calves, Gatifloxacin, Meloxicam, Pharmacokinetics

Abstract

The pharmacokinetics of intravenously administered gatifloxacin, upon concomitant administration with meloxicam was investigated in buffalo calves. Meloxicam was administered subcutaneously (0.5 mg.kg-1) immediately followed by intravenous administration of Gatifloxacin (4 mg.kg-1). The concentration of gatifloxacin was estimated in plasma by microbiological assay. Pharmacokinetic parameters were calculated and appropriate dosage schedule was computed. The therapeutic plasma drug concentration was maintained up to 12 h. Gatifloxacin was rapidly distributed from blood to tissue compartment, which was evident from the high values of distribution rate constant, α1 (11.9 ± 0.52 h-1) and the ratio of rate constant of transfer of drug from central to peripheral compartments and vice versa, K12/K21 (3.05 ± 0.36) and K13/K31 (2.04 ± 0.12). The area under the plasma drug concentration-time curve and apparent volume of distribution were 12.0 ± 0.68 µg.ml-1.h and 2.69 ± 0.14 L.kg-1, respectively. The elimination half-life (t1/2β), total body clearance (ClB) and the ratio of drug present in peripheral to central compartment (P/C) were 5.59 ± 0.40 h, 337.6 ± 19.9 ml.kg-1.h-1 and 8.04 ± 0.50, respectively. The present study revealed that the most suitable dosage regimen of gatifloxacin when concomitantly administered with meloxicam in buffalo calves would be 2.5 mg.kg-1 followed by 2.0 mg.kg-1 at 12 h intervals.

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Published

2010-12-01

How to Cite

Dumka, V. K., Sandhu, H. S., & Rajput, N. (2010). Plasma levels, pharmacokinetics and dosage regimen of intravenously administered gatifloxacin in buffalo calves (Bubalus bubalis) on coadministration with meloxicam. Brazilian Journal of Veterinary Research and Animal Science, 47(6), 461-467. https://doi.org/10.11606/issn.1678-4456.bjvras.2010.26808

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