Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol

  • Fabiana Augusta Ikeda-Garcia Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP
  • Raimundo Souza Lopes Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP
  • Fábia Judice Marques Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP
  • Paulo César Ciarlini Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP
  • Valéria Marçal Félix de Lima Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP
  • Celina Kazue Morinishi Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP
  • Maurício Franco Zanette Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP
  • Sílvia Helena Venturoli Perri Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP
  • Mary Marcondes Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP
Keywords: Dogs, Visceral leishmaniasis, Treatment, Allopurinol, Meglumine antimoniate

Abstract

Aiming to assess the efficacy of the treatment, to verify the occurrence of possible disease relapses and to search for the presence of parasites after the treatment, seven dogs naturally infected by Leishmania sp., were submitted to a treatment with meglumine antimoniate and allopurinol. For this, lymph node and bone marrow aspiration biopsies were carried out at seven moments. After the end of the six-month observation period all dogs were submitted to euthanasia. Then, spleen and liver "imprints" and in vitro cultures were carried out to search for amastigote forms of the parasite. All animals presented remission of the symptoms and during all the observation period no dog presented relapse of the disease, although amastigote forms of the parasite were observed in two of the animals at the end of the experiment. Thus, it was possible to conclude that the treatment promotes clinical healing but it does not eliminate the parasites completely.

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Published
2010-06-01
How to Cite
Ikeda-Garcia, F., Lopes, R., Marques, F., Ciarlini, P., Lima, V., Morinishi, C., Zanette, M., Perri, S., & Marcondes, M. (2010). Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate and allopurinol. Brazilian Journal of Veterinary Research and Animal Science, 47(3), 218-223. https://doi.org/10.11606/issn.1678-4456.bjvras.2010.26859
Section
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