Participation of the pathway alfa-2

  • Emiliana de Oliveira Santana Batista Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Botucatu, SP
  • Daniel Cardoso Agência Paulista de Tecnologia dos Agronegócios, Pólo Extremo Oeste, Andradina, SP
  • Guilherme de Paula Nogueira Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Botucatu, SP
Keywords: Nelore, Prepubertal, GH, Clonidine

Abstract

This study investigated GH secretion after clonidine (alpha-2 adrenergic agonist) treatmentin pre-pubertal Nelore heifers. Clonidine (10mg/kg, IV, 15 min samples for 4h) was administrated in the same Nelore heifers at eight (n = 4), 12 (n = 5) and 15 (n = 4) months of age. The GH concentration was measured by radioimmunoassay (sensivity = 0.25 ng/mL, CV = 16%). At eight months, clonidine increased GH average concentration, total area of peaks, the total area of GH secretion and increased peak amplitude and reduced time to onset of peak (P < 0.05). At 15 months, the administration of clonidine increased the GH average concentration and at 12 months the increased occurred only in restricted intervals (P <0.05). Clonidine injection stimulated GH secretion in prepubertal heifers and this effect was more evident in Nelore heifers at eight months compared to 12 and 15 months of age.

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Published
2011-08-01
How to Cite
Batista, E., Cardoso, D., & Nogueira, G. (2011). Participation of the pathway alfa-2. Brazilian Journal of Veterinary Research and Animal Science, 48(4), 325-331. https://doi.org/10.11606/S1413-95962011000400008
Section
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