Effect of the ethanolic extract from green propolis on production of antibodies after immunization against canine parvovirus (CPV) and canine coronavirus (CCoV)

  • Lílian das Neves Ferreira Universidade Federal de Pelotas, Faculdade de Medicina Veterinária, Departamento de Veterinária Preventiva, Pelotas, RS
  • Paula Fonseca Finger Universidade Federal de Pelotas, Faculdade de Medicina Veterinária, Departamento de Veterinária Preventiva, Pelotas, RS
  • Clarissa Caetano de Castro Universidade Federal de Pelotas, Faculdade de Medicina Veterinária, Departamento de Veterinária Preventiva, Pelotas, RS
  • Bianca Sica Siedler Universidade Federal de Pelotas, Faculdade de Medicina Veterinária, Departamento de Veterinária Preventiva, Pelotas, RS
  • Lívia Silveira Munhoz Universidade Federal de Pelotas, Faculdade de Medicina Veterinária, Departamento de Veterinária Preventiva, Pelotas, RS
  • Gilberto D’Avila Vargas Universidade Federal de Pelotas, Faculdade de Medicina Veterinária, Departamento de Veterinária Preventiva, Pelotas, RS
  • Geferson Fischer Universidade Federal de Pelotas, Faculdade de Medicina Veterinária, Departamento de Veterinária Preventiva, Pelotas, RS
  • Silvia de Oliveira Hübner Universidade Federal de Pelotas, Faculdade de Medicina Veterinária, Departamento de Veterinária Preventiva, Pelotas, RS
Keywords: Propolis, Th1/Th2, Immunomodulation, Vaccine, Canine parvovirus, Canine coronavirus

Abstract

This study was designed to evaluate whether an ethanolic extract of green propolis (EEP) can interfere with production of specific antibodies after immunization against parvovirus (CPV) and canine coronavirus (CCoV). Mice were vaccinated with CPV and CCoV (0.75, 1.5 and 3 x 106 TCID50) with or without 400 μg/dose of the EEP. Twenty one days after the third dose was measured serum IgG. The co-administration of the EEP significantly enhanced serum specific IgG responses to CPV in animals inoculated with the highest concentration of the antigen, and had no influence on levels of antibodies to CCoV. The results indicate that the EEP has immunomodulatory action closely dependent on the type and concentration of antigen used, being able to increase the levels of antibodies to CPV.

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Published
2012-04-03
How to Cite
Ferreira, L., Finger, P., Castro, C., Siedler, B., Munhoz, L., Vargas, G., Fischer, G., & Hübner, S. (2012). Effect of the ethanolic extract from green propolis on production of antibodies after immunization against canine parvovirus (CPV) and canine coronavirus (CCoV). Brazilian Journal of Veterinary Research and Animal Science, 49(2), 116-121. https://doi.org/10.11606/issn.2318-3659.v49i2p116-121
Section
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