Significant hematocrit decrease in healthy horses during clinical anesthesia

  • Aline Magalhães Ambrósio Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Keila Kazue Ida Universidade de São Paulo, Faculdade de Medicina, Laboratório de Investigação Médica, São Paulo, SP
  • Maria Teresa de Melo Rego Souto Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Luis Claudio Lopes Correia da Silva Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Paolo Bona Soares Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Bruna Trentinaro Ibiapina Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Hospital Veterinário, São Paulo, SP
  • Tiago Marcelo Oliveira Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Clínica Médica, São Paulo, SP
  • Gustavo Miranda Zanotto Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Denise Tabacchi Fantoni Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
Keywords: Horse, Hematocrit, Packed cell volume, Xylazine, Acepromazine

Abstract

Xylazine (XYL) and acepromazine (ACP) are known to decrease the hematocrit (HT) of horses when administered alone. However in routine anesthesia these drugs are administered by associations which ultimate effect in the HT is unknown but may cause false impressions about the hydration status, blood loss and red blood cell indices. The objective of this study was to characterize the values of HT in horses anesthetized with XYL, ACP, ketamine, midazolam, guaiphenesin, isoflurane and ephedrine. Twenty healthy horses were premedicated with either XYL 0.8 mg/kg (XYL group, n=10) or XYL 0.5 mg/kg plus ACP 0.05 mg/kg (XYL+ACP group, n=10). Anesthesia was induced with ketamine, midazolam and guaiphenesin and maintained with isoflurane. Ephedrine was infused for cardiovascular support. HT, vital parameters and blood gas values were evaluated at baseline, between each drug administration, after standing and 24 hours after baseline (24hBL). The HT started to decrease 17 and 40 minutes after premedication in XYL group and XYL+ACP group, respectively (p<0.05). The maximum decrease of 19% in XYL group and 17% in XYL+ACP group was observed after 1 hour of premedication (p<0.05). In both groups HT remained low for longer than 180 minutes and returned to baseline at 24hBL. A significant HT decrease should be considered in anesthetized healthy horses receiving XYL, ACP, ketamine, midazolam, guaiphenesin, isoflurane and ephedrine.

Downloads

Download data is not yet available.
Published
2012-04-03
How to Cite
Ambrósio, A., Ida, K., Souto, M. T., Silva, L. C., Soares, P., Ibiapina, B., Oliveira, T. M., Zanotto, G., & Fantoni, D. (2012). Significant hematocrit decrease in healthy horses during clinical anesthesia. Brazilian Journal of Veterinary Research and Animal Science, 49(2), 139-145. https://doi.org/10.11606/issn.2318-3659.v49i2p139-145
Section
UNDEFINIED

Most read articles by the same author(s)

1 2 > >>