Quantitative evaluation of tuberculosis evolution in hamsters submitted to an eight-week Trichlorfon treatment and infected with Mycobacterium bovis, strain AN5

  • José Soares Ferreira Neto Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Sonia Regina Pinheiro Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Zenaide Maria Moraes Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Luiz Carlos Sá Rocha Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Idércio Luiz Sinhorini Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Fumio Homma Ito Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Silvio Arruda Vasconcellos Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
Keywords: Hamsters, Mycobacterium bovis, Trichlorfon.

Abstract

The evolution of disease by intraperitoneal inoculation of Mycobacterium bovis (strain AN5) was evaluated in hamsters (Mesocricetus auratus) treated daily, from Monday to Friday, with 30 mg/kg of Trichlorfon given subcutaneously, for a period of 8 consecutive weeks. The criteria used for the evaluation were post infection survival time and quantitative cultures of mycobacteria from spleen, kidney, liver and lung taken at 1, 15, 29 and 45 days after inoculation.
Histopathologic examinations were also performed at each scheduled time. Treated and control animals developed progressive disease. The results of quantitative cultures and survival time after inoculation were not influenced by
Trichlorfon as related to the evolution of tuberculosis.

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Published
1996-09-01
How to Cite
Ferreira Neto, J., Pinheiro, S. R., Moraes, Z. M., Rocha, L. C., Sinhorini, I. L., Ito, F., & Vasconcellos, S. (1996). Quantitative evaluation of tuberculosis evolution in hamsters submitted to an eight-week Trichlorfon treatment and infected with Mycobacterium bovis, strain AN5. Brazilian Journal of Veterinary Research and Animal Science, 33(3), 139-143. https://doi.org/10.11606/issn.2318-3659.v33i3p139-143
Section
BASIC SCIENCES