Quantitative evaluation of tuberculosis evolution in hamsters submitted to an eight-week Trichlorfon treatment and infected with Mycobacterium bovis, strain AN5
AbstractThe evolution of disease by intraperitoneal inoculation of Mycobacterium bovis (strain AN5) was evaluated in hamsters (Mesocricetus auratus) treated daily, from Monday to Friday, with 30 mg/kg of Trichlorfon given subcutaneously, for a period of 8 consecutive weeks. The criteria used for the evaluation were post infection survival time and quantitative cultures of mycobacteria from spleen, kidney, liver and lung taken at 1, 15, 29 and 45 days after inoculation.
Histopathologic examinations were also performed at each scheduled time. Treated and control animals developed progressive disease. The results of quantitative cultures and survival time after inoculation were not influenced by
Trichlorfon as related to the evolution of tuberculosis.
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