Regeneration of peripheral nerve fibres following Haloxon-induced degeneration

  • Maria Veronica de Souza Universidade Federal de Viçosa, Viçosa, MG
  • Dominguita Luhers Graça Universidade Federal de Santa Maria, Departamento de Patologia, Santa Maria, RS
  • Sandro Narciso Nunes Ferrão Universidade Federal de Santa Maria, Departamento de Patologia, Santa Maria, RS
  • Emerson Antônio Contesini Universidade Federal de Mato Grosso, Cuiabá, MT
Keywords: Haloxon, Poisoning, Sheep, Neurotoxins, Nerve regeneration

Abstract

Delayed neurotoxicity has been associated with organophosphorus poisoning for years. In order to study such condition in sheep, 11 animals were given either one or two high doses of Haloxon. Exposed sheep were observed daily and between 16 and 25 days after administration neurological signs as incoordination and ataxia were detected in six of them. Biopsies of tibial and laryngeal nerves were performed as soon as neurotoxicity was diagnosed, and after death fragments of selected nerves were collected together with CNS tissues for light and electron microscopy and teased fiber studies. Laryngeal, tibial and sciatic nerves showed the most pronouced changes, consisting chiefly of wallerian degeneration that was seen either as a single fiber or as a complete fascicle feature. Exams performed after death clearly showed regenerating fascicles with axonal sprouts growing within a Schwann cell old basal lamina, and some thinly myelinated axonal sprouts.

Downloads

Download data is not yet available.
Published
1996-12-01
How to Cite
Souza, M. V. de, Graça, D., Ferrão, S., & Contesini, E. A. (1996). Regeneration of peripheral nerve fibres following Haloxon-induced degeneration. Brazilian Journal of Veterinary Research and Animal Science, 33(4), 231-234. https://doi.org/10.11606/issn.2318-3659.v33i4p231-234
Section
ANIMAL PATHOLOGY