Effect of different vehicles in carrageenan suspension on the rate of the inflammatory response of chicks

  • Alda Maria Backx Noronha Madeira Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP.
  • Nair Massako Katayama Ito Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP.
  • Maria Regina Baccaro Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP.
Keywords: Carrageenan, Hens, Inflammation

Abstract

This paper describes the pattern of edema, increased vascular permeability and cellular exudation elicited by the injection of different carrageenan suspensions into the foot pad of 80 male chicks, three to four-week old. Carrageenan suspensions at 0.5% were prepared in: Ringer Locke solution (RL), glucose aqueous solution 0.1% (G), demineralized water (W) or phosphate buffered saline (PBS). The foot pad volume and vascular permeability were evaluated by pletismography and by Evans blue extravasation, respectively, before and at 0:15, 0:30, 1:00, 1:30, 2:00, 2:30, 3:00, 3:30 and 4:00 hours after injury. Cellular exudation was observed in thin sections of stained tissue 0:30, 1:30, 2:30 and 4:00 hours after injection of the carrageenan or vehicle only. The inflammatory response varied according to the carrageenan suspension used. Suspension C/PBS induced a less intense inflammatory response in foot pads of chicks than C/W, C/G and C/RL suspensions.

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Published
1995-12-04
How to Cite
Madeira, A. M., Ito, N., & Baccaro, M. R. (1995). Effect of different vehicles in carrageenan suspension on the rate of the inflammatory response of chicks. Brazilian Journal of Veterinary Research and Animal Science, 32(4), 213-218. https://doi.org/10.11606/issn.1678-4456.bjvras.1994.52111
Section
BASIC SCIENCES