Chloramphenicol restores the polymorphonuclear accumulation in carrageenin-induced pleurisy in diabetic rats

Authors

  • Julieta Rodini Engrácia de Moraes Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Departamento de Patologia Veterinária, Jaboticabal, SP
  • Flávio Ruas de Moraes Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Departamento de Patologia Veterinária, Jaboticabal, SP
  • Jair Rodini Engrácia Filho Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Departamento de Patologia Veterinária, Jaboticabal, SP

DOI:

https://doi.org/10.1590/S1413-95961998000600002

Keywords:

Chloramphenicol, Diabetes, Pleurisia, Neutrophils

Abstract

We investigated the effect of chloramphenicol succinate (30 mg/kg, every 12 h for 4 days, ip) on the reduced polymorphonuclear leukocytes (PMN) accumulation in carrageenin-induced pleurisy (150 mug) in diabetic (alloxan, 40 mg/kg, IV) rats (Wistar, males, 180-320 g, n = 12). Chloramphenicol produced an increase (p<0.05) on PMN count in pleural exudate of 36% in normal animals. In the animals non-treated with chloramphenicol the diabetes state reduced (p<0.05) the accumulation of PMN cells by 45%. In diabetic animals treated with chloramphenicol the number of PMN in pleural exudate was similar to the one observed in the control group. Total and differential counts of leukocytes in the peripheral blood were similar between groups before and 4 h after the carrageenin-injection.

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Published

1998-01-01

Issue

Vol. 35 No. 6 (1998)

Section

BASIC SCIENCES

License

The journal content is authorized under the Creative Commons  BY-NC-SA  license (summary of the license: https://creativecommons.org/licenses/by-nc-sa/4.0 | full text of the license: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode) 

How to Cite

1.
Moraes JRE de, Moraes FR de, Engrácia Filho JR. Chloramphenicol restores the polymorphonuclear accumulation in carrageenin-induced pleurisy in diabetic rats. Braz. J. Vet. Res. Anim. Sci. [Internet]. 1998 Jan. 1 [cited 2024 Apr. 23];35(6):243-5. Available from: https://revistas.usp.br/bjvras/article/view/5673