Controlled mechanical ventilation in horses under vecuronium blockage

Authors

  • Denise Tabacchi Fantoni Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • José de Alvarenga Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Luis Claudio Lopes Correia da Silva Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Silvia Renata Gaido Cortopassi Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Regina Mieko Sakata Mirandola Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP

DOI:

https://doi.org/10.1590/S1413-95961998000400008

Keywords:

Mechanical ventilation, Vecuronium, General anesthesia, Horses

Abstract

The purpose of this study was to investigate the metabolic and cardiorespiratory effects of the administration of vecuronium under controlled mechanical ventilation versus spontaneous ventilation in horses. Twenty healthy horses scheduled to elective surgery were randomized and assigned in two groups. All animals were pre-medicated with romifidine (100 mu g/kg iv), anesthesia was induced with an association of tiletamine-zolazepam (2 mg/kg iv) and was maintained with halothane. Animals of group I remained in spontaneous ventilation without muscle relaxation while group II received vecuronium (0.1 mg/kg IV) and was submitted to controlled mechanical ventilation. Vecuronium administration did not cause any significant change of heart rate or rhythm, central venous pressure and arterial pressure. With the animals that remained under spontaneous ventilation, no differences were observed in these parameters. The animals that received vecuronium showed lower values of PaCO2 and normal values of pH in relation to the spontaneous ventilation group. Vecuronium duration was 12.83 ± 1.72 minutes. After halothane discontinuation the weaning time in group I I was 6.09 minutes with mean final PaCO2 values of 50.78 mmHg. There was no need of pharmacological reversion of vecuronium effect and recovery from anesthesia was similar in the two groups. In conclusion, the use of mechanical controlled ventilation and vecuronium in horses is easily performed, does not induce further cardiovascular depression and should be employed in equines undergoing major operations.

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Published

1998-01-01

How to Cite

Fantoni, D. T., Alvarenga, J. de, Silva, L. C. L. C. da, Cortopassi, S. R. G., & Mirandola, R. M. S. (1998). Controlled mechanical ventilation in horses under vecuronium blockage. Brazilian Journal of Veterinary Research and Animal Science, 35(4), 182-187. https://doi.org/10.1590/S1413-95961998000400008

Issue

Section

VETERINARY MEDICINE

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