Clinical evaluation of nervous ketosis induced by isopropanol in sheep

  • Carolina Akiko Sato Cabral Araújo Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Clínica Médica Veterinária, São Paulo, SP
  • Frederico Augusto Mazzocca Lopes Rodrigues Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Clínica Médica Veterinária, São Paulo, SP
  • Antonio Humberto Hamad Minervino Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Clínica Médica Veterinária, São Paulo, SP
  • Braulio Frateschi Trivelatto Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Clínica Médica Veterinária, São Paulo, SP
  • Leonardo Frasson dos Reis Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Clínica Médica Veterinária, São Paulo, SP
  • Clara Satsuki Mori Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Clínica Médica Veterinária, São Paulo, SP
  • Enrico Lippi Ortolani Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Clínica Médica Veterinária, São Paulo, SP
Keywords: Sheep, Symptoms, Nervous, Ketone bodies, Pregnancy Toxaemia

Abstract

Twelve healthy Santa Ines sheep, non-pregnant and non-lactating underwent a protocol of experimental induction of nervous ketosis for studying the symptoms in ketosis and Pregnancy Toxaemia (PT) disease. Eight animals were subjected to infusion of 150 mL of isopropanol (IPA) at 35% in the jugular vein and four sheep were treated identically with isotonic saline solution (NaCl 0.9%) during 40 minutes. The animals treated with IPA showed increased heart rate (HR) after 40 minutes of infusion and decreased ruminal movement from the 10 minutes infusion with IPA and remaining low up to 10 minutes from the end of the infusion. Ruminal atony appeared in three animals, which showed slight meteorism gas. Infusion of IPA caused the appearance of nervous symptoms as depression, staggering, adduction of hind limbs, head pressing, teeth grind and blindness almost always accompanied by a decreased pupillary reflex and nystagmus. All the animals exhaled ketosis breath with strong odor within few minutes of the start of induction that helped the elimination of the IPA from the organism. The present results strongly suggest that part of the nervous symptoms observed in PT may be derived from the action of IPA. These present findings open new perspectives for a better understanding of the pathogenesis of PT in sheep.

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Published
2013-12-09
How to Cite
Araújo, C., Rodrigues, F., Minervino, A. H., Trivelatto, B., Reis, L., Mori, C., & Ortolani, E. (2013). Clinical evaluation of nervous ketosis induced by isopropanol in sheep. Brazilian Journal of Veterinary Research and Animal Science, 50(6), 493-496. https://doi.org/10.11606/issn.1678-4456.v50i6p493-496
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