Neutralizing antibodies to bovine herpesviruses types 1 (BHV-1) and 5 (BHV-5) induced by an experimental, oil-adjuvanted, BHV-1 vaccine

Authors

  • Sylio Alfredo Petzhold Fundação Estadual de Pesquisa Agropecuária, Centro de Pesquisa Veterinária Desidério Finamor
  • Paulo Estanislao Reckziegel Fundação Estadual de Pesquisa Agropecuária, Centro de Pesquisa Veterinária Desidério Finamor
  • José Antonio Pires Prado Fundação Estadual de Pesquisa Agropecuária, Centro de Pesquisa Veterinária Desidério Finamor
  • João Carlos Teixeira Fundação Estadual de Pesquisa Agropecuária, Centro de Pesquisa Veterinária Desidério Finamor
  • Vera Beatriz Wald Universidade Federal do Rio Grande do Sul, Faculdade de Veterinária, Departamento de Clínica
  • Paulo Augusto Esteves Fundação Estadual de Pesquisa Agropecuária, Centro de Pesquisa Veterinária Desidério Finamor
  • Fernando Rosado Spilki Fundação Estadual de Pesquisa Agropecuária, Centro de Pesquisa Veterinária Desidério Finamor
  • Paulo Michel Roehe Universidade Federal do Rio Grande do Sul, Instituto de Ciências Básicas da Saúde, Departamento de Microbiologia

DOI:

https://doi.org/10.1590/S1413-95962001000400007

Keywords:

BHV-1, BHV-5, Bovine herpesvirus, Experimental vaccine, Inactivated vaccine, Neutralizing antibodies

Abstract

An experimental oil-adjuvanted, inactivated vaccine against bovine herpesvirus type 1 (BHV-1.1), was produced and evaluated in its capacity to induce neutralizing antibodies against bovine herpesvirus type 1 (BHV-1, subtypes 1.1 and 1.2) and bovine herpesvirus type 5 (BHV-5). Cattle were vaccinated and revaccinated 90 days later. Antibodies were measured at days 0, 30, 90, 120, 180, 270 and 450 days after the first dose of vaccine (DPV). Antibody titres to BHV-1.1 and BHV-1.2 were significantly higher than to BHV-5 throughout the experiment. While all calves seroconverted to BHV-1.1 and BHV-1.2 after the first dose of vaccine, only two out of 23 (8,7%) calves seroconverted to BHV-5. However, after the booster injection all animals seroconverted to the three virus types. At 450 DPV, 79% (15/19 cattle) and 84% (16/19) were still positive for antibodies to BHV 1.1 and BHV 1.2, whereas 50% (10/19) of the calves remained seropositive for BHV-5. It was concluded that although a potent BHV-1 vaccine may induce crossreactive neutralizing antibodies to BHV-5, the levels of such antibodies are significantly lower and of shorter duration than antibodies to BHV-1.1 or BHV-1.2.

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Published

2001-01-01

Issue

Section

VETERINARY MEDICINE

How to Cite

Neutralizing antibodies to bovine herpesviruses types 1 (BHV-1) and 5 (BHV-5) induced by an experimental, oil-adjuvanted, BHV-1 vaccine. (2001). Brazilian Journal of Veterinary Research and Animal Science, 38(4), 184-187. https://doi.org/10.1590/S1413-95962001000400007