Humoral immune response in capuchin monkeys (Cebus apella) kept in captivity after a booster dose with a veterinary use suckling mouse brain rabies vaccine

  • Estevão de Camargo Passos Instituto Pasteur, São Paulo, SP
  • Pedro Manuel Leal Germano Instituto Pasteur, São Paulo, SP
  • José Daniel Luzes Fedullo Fundação Parque Zoológico, São Paulo, SP
  • Cleide Aschenbrenner Consales Instituto Pasteur, São Paulo, SP
  • Maria Luiza Carrieri Instituto Pasteur, São Paulo, SP
  • Ricardo Cardoso Faculdades Metropolitanas Unidas, São Paulo, SP
  • Margareth de Andrade Gonçalves Faculdades Metropolitanas Unidas, São Paulo, SP
Keywords: Capuchin monkeys, Cebus apella, Rabies, SMBV, Neutralizing antibodies, Immunization

Abstract

Twenty-six capuchin monkeys (Cebus apella) were intramuscularly immunized with 1.0 ml dose of a veterinary inactivated suckling mouse brain rabies vaccine (SMBV) employed in campaigns for rabies prevention in dogs and cats. The animals belonged to three experimental groups previously vaccinated with SMBV and different schemes, were kept in captivity from June, 1996 to June, 1997. All animals received a booster dose. Serum samples were obtained at the 0th, 30 th, 180th and 365 th days and kept stored at -20ºC. The antibodies dosage was carried out through the simplified inhibition fluorescent test. After a booster dose 17/25 (68%) of animals belonged to groups I, II and III, that had neutralizing antibodies above 0.5 IU/ml produced a humoral immune response equal or higher than 0.5 IU/ml, and another five animals that had neutralizing antibodies higher than 0.5 IU/ml kept in these levels. In relationship to longer humoral immune response there is no statistical difference between all groups, G-I x G-II, G-I x GIII, G-II x G-III (p>;0,05). The SMBV induced humoral immune response in capuchin monkeys after a booster dose, producing neutralizing antibodies equal to or higher than 0.5 IU/ml; however, they were short-lasting, being therefore not appropriate as an immunogen to be used routinely in the immunization of these animals which are difficult both to be dealed with and to be kept in captivity.

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Published
2002-01-01
How to Cite
Passos, E., Germano, P., Fedullo, J., Consales, C., Carrieri, M., Cardoso, R., & Gonçalves, M. (2002). Humoral immune response in capuchin monkeys (Cebus apella) kept in captivity after a booster dose with a veterinary use suckling mouse brain rabies vaccine. Brazilian Journal of Veterinary Research and Animal Science, 39(4), 181-188. https://doi.org/10.1590/S1413-95962002000400004
Section
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