Implantation of two biological membranes in a corneal micropocket as an experimental model for angiogenesis

  • Angélica de Mendonça Vaz Safatle Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Paulo Sergio de Moraes Barros Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Benjamin Eurico Malucelli Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, São Paulo, SP
  • José Luiz Guerra Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, São Paulo, SP
Keywords: Angiogenesis, Cornea, Biological membranes, Experimental model, Rat

Abstract

Angiogenesis has been known to participate in several physiological and pathological processes. Experimental models have been utilized to demonstrate its importance. The aim of this study was to establish an angiogenesis model using two biological membranes (pericardium and amniotic membrane) preserved in glycerin. The membranes were implanted in a micropocket in the cornea of 63 rats. The pericardium was implanted into the right cornea and the amniotic into the left cornea of the same animal. The rats were sacrificed at 1, 3, 7, 15, 30 and 60 days after the surgical procedure and the specimens underwent histology examination. Although the pericardium was more effective to induce angiogenesis and for a long period of time when compared to the amniotic membrane, both membranes can be used as an angiogenesis model.

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Published
2002-01-01
How to Cite
Safatle, A., Barros, P., Malucelli, B., & Guerra, J. (2002). Implantation of two biological membranes in a corneal micropocket as an experimental model for angiogenesis. Brazilian Journal of Veterinary Research and Animal Science, 39(4), 189-195. https://doi.org/10.1590/S1413-95962002000400005
Section
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