The carcinogenic potential of cadmium in the palatal and gingival epithelium of rats: a morphologic and morphometric analysis

  • Ana Carolina Fragoso Motta Universidade de São Paulo, Faculdade de Odontologia, Departamento de Diagnóstico Bucal, São Paulo, SP
  • Dante Antonio Migliari Universidade de São Paulo, Faculdade de Odontologia, Departamento de Diagnóstico Bucal, São Paulo, SP
  • Marco Antonio Gioso Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Marilena Chinali Komesu Universidade de São Paulo, Faculdade de Odontologia, Departamento de Morfologia, Estomatologia e Fisiologia, Ribeirão Preto, SP
  • Miguel Angel Sala Universidade de São Paulo, Faculdade de Odontologia, Departamento de Morfologia, Estomatologia e Fisiologia, Ribeirão Preto, SP
  • Ruberval Armando Lopes Universidade de São Paulo, Faculdade de Odontologia, Departamento de Morfologia, Estomatologia e Fisiologia, Ribeirão Preto, SP
Keywords: Cadmium chloride, Ooral cancer, Carcinogenesis, Rat

Abstract

Cadmium (Cd) is a heavy metal that exerts a variety of toxic effects, chronic and acute, in exposed organisms. The aim of this study was to investigate the carcinogenic potential of Cd in the palatal and gingival epithelium of Wistar rats. Two groups of animals were studied: group 1 consisted of 5 rats exposed to cadmium chloride (CdCl2) in drinking water (300 mg/L) for 6 months; group 2 also consisted of 5 rats placed in the same conditions as those of group 1, but kept free of Cd for 6 additional months. Two other groups (C1 and C2) with the same number of animals, but not exposed to CdCl2, were used as a control for groups 1 and 2, respectively. All animals were weighed before and after the experimental period. After animals being killed, tissues of interest were fixed in solution of 10% formalin, processed by standard histologic techniques, stained with HE, and analyzed under light microscopy using karyometric and stereologic parameters. Loss of body weight, atrophy of the gingiva and soft-palate epithelium were the principal findings of this study, and verified only in the group 1 (p < 0.05). In conclusion, at the concentration tested, Cd presented no carcinogenic effect on the oral tissues within the experimental time period.

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Published
2004-06-01
How to Cite
Motta, A., Migliari, D., Gioso, M., Komesu, M., Sala, M., & Lopes, R. (2004). The carcinogenic potential of cadmium in the palatal and gingival epithelium of rats: a morphologic and morphometric analysis. Brazilian Journal of Veterinary Research and Animal Science, 41(3), 183-188. https://doi.org/10.1590/S1413-95962004000300006
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