Reproductive toxicity of Samanea tubulosa on rats

  • Maria Rafaella Luz de Araújo Universidade Federal de Tocantins, Escola de Medicina Veterinária e Zootecnia
  • Karlla de Freitas Nunes Universidade Federal de Tocantins, Escola de Medicina Veterinária e Zootecnia
  • Larissa Vieira Costa Universidade Federal de Tocantins, Escola de Medicina Veterinária e Zootecnia
  • Benta Natânia Silva Figueiredo Universidade Federal de Tocantins, Escola de Medicina Veterinária e Zootecnia
  • Domenica Palomaris Mariano-Souza Universidade Federal de Tocantins, Escola de Medicina Veterinária e Zootecnia
  • Adriano Tony Ramos Universidade Federal de Santa Catarina, Medicina Veterinária
  • Sandro Estevan Moro Universidade Federal de Tocantins, Escola de Medicina Veterinária e Zootecnia
  • Joseilson Alves de Paiva Universidade Federal de Tocantins, Escola de Medicina Veterinária e Zootecnia
  • Helenice de Souza Spinosa Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia
  • Viviane Mayumi Maruo Universidade Federal de Tocantins, Escola de Medicina Veterinária e Zootecnia
Keywords: Cattle, Fertility, Phytotherapy, Plant, Reproductive toxicology

Abstract

Samanea tubulosa is a plant used for medicinal and feeding purposes. However, ingestion of S. tubulosa pods has been associated with bovine abortion. Thus, the aim of this work was to investigate the effects of diet containing 5% of S. tubulosa pod meal on male and female Wistar rats. Diet was administered to male rats (n = 10) for 60 days before mating. Female rats (n = 10) received the treatment for 30 days, during cohabitation and from gestational day (GD) 0 to GD20. Treated animals were mated with untreated rats. In male rats, plant consumption caused decreased food consumption and 20% fertility index reduction. Litters from treated males presented lower body weight and crown–rump length. Female rats treated with the plant increased water and food intake and body weight. Decreases in fertility, fecundity and gestation indices and increase of placenta weight and mean number of corpora lutea were found. Thus, owing to the possible general and reproductive toxic effects, long-term consumption of S. tubulosa is not recommended for phytotherapic or food purposes.

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Published
2015-12-10
How to Cite
Araújo, M. R., Nunes, K., Costa, L., Figueiredo, B., Mariano-Souza, D., Ramos, A., Moro, S., Paiva, J., Spinosa, H., & Maruo, V. (2015). Reproductive toxicity of Samanea tubulosa on rats. Brazilian Journal of Veterinary Research and Animal Science, 52(4), 342-349. https://doi.org/10.11606/issn.1678-4456.v52i4p342-349
Section
ARTICLES