p38MAPK plays a pivotal role in the development of acute respiratory distress syndrome

Authors

DOI:

https://doi.org/10.6061/clinics/2019/e509

Keywords:

ARDS, p38MAPK, Pathophysiology

Abstract

Acute respiratory distress syndrome (ARDS) is a life-threatening illness characterized by a complex pathophysiology, involving not only the respiratory system but also nonpulmonary distal organs. Although advances in the management of ARDS have led to a distinct improvement in ARDS-related mortality, ARDS is still a lifethreatening respiratory condition with long-term consequences. A better understanding of the pathophysiology of this condition will allow us to create a personalized treatment strategy for improving clinical outcomes. In this article, we present a general overview p38 mitogen-activated protein kinase (p38MAPK) and recent advances in understanding its functions. We consider the potential of the pharmacological targeting of p38MAPK pathways to treat ARDS.

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Published

2019-08-19

How to Cite

Feng, Y., Fang, Z., Liu, B., & Zheng, X. (2019). p38MAPK plays a pivotal role in the development of acute respiratory distress syndrome. Clinics, 74, e509. https://doi.org/10.6061/clinics/2019/e509

Issue

Section

Review Articles