Imaging modalities in medication-related osteonecrosis of the jaw

a literature review

Authors

  • Wellington Hideaki Yanaguizawa Universidade de São Paulo
  • Solange Kobayashi Velasco Universidade de São Paulo
  • Rodrigo Lima Petersen Private Practice
  • Fábio de Abreu Alves Universidade de São Paulo
  • Marcelo Gusmão Paraíso Cavalcanti Universidade de São Paulo

DOI:

https://doi.org/10.11606/issn.2357-8041.clrd.2020.164723

Keywords:

Osteonecrosis, Panoramic Radiography, X-ray Computed Tomography, Magnetic Resonance Imaging, Radionuclide Imaging

Abstract

Osteonecrosis occurs by cellular death of the bone tissue due to an irreversible external factor. This disorder may be clinically unidentified in the early stages and result in degradation of the bone architectural structure, leading to pain, bone destruction, and loss of function. Thus, imaging exams become relevant to the recognition and definition of the bone necroses. The aim of this study was to review the literature on imaging exams frequently used for the diagnosis and evaluation of patients undergoing drug therapies associated with osteonecrosis of the jaw, such as panoramic radiography, computed tomography, magnetic resonance imaging and bone scintigraphy.

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Author Biographies

Wellington Hideaki Yanaguizawa, Universidade de São Paulo

Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, SP, Brazil.

Solange Kobayashi Velasco, Universidade de São Paulo

Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, SP, Brazil.

Fábio de Abreu Alves, Universidade de São Paulo

Department of Stomatology, School of Dentistry, Universidade de São Paulo, São Paulo, SP, Brazil.

Marcelo Gusmão Paraíso Cavalcanti, Universidade de São Paulo

Department of Stomatology, School of Dentistry, Universidade de São Paulo, São Paulo, SP, Brazil.

References

Fondi C, Franchi A. Definition of bone necrosis by the pathologist. Clin Cases Miner Bone Metab. 2007;4(1):21-6.

Ruggiero SL, Dodson TB, Fantasia J, Godday R, Aghaloo T, Mehrotra B, et al. American Association of Oral and Maxillofacial Surgeons Position Paper on Medication-Related Osteonecrosis of the Jaw-2014 Update. J Oral Maxillofac Surg. 2014;72(10):1938-56. doi: https://doi.org/10.1016/j.joms.2014.04.031

Wilde F, Heufelder M, Lorenz K, Liese J, Helmrich J, Schramm A, et al. Prevalence of cone beam computed tomography imaging findings according to the clinical stage of bisphosphonate-related osteonecrosis of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114(6):804-11. doi: https://doi.org/10.1016/j.oooo.2012.08.458

Miyashita H, Shiba H, Kawana H, Nakahara T. Clinical utility of three-dimensional SPECT/CT imaging as a guide for the resection of medication-related osteonecrosis of the jaw. Int J Oral Maxillofac Surg. 2015;44(9):1106-9. doi: https://doi.org/10.1016/j.ijom.2015.05.002

Phal PM, Myall RWT, Assael LA, Weissman JL. Iumaging findings of bisphosphonate-associated osteonecrosis of the jaws. Am J Neuroradiol. 2007;28(6):1139-45. doi: https://doi.org/10.3174/ajnr.A0518

Guggenberger R, Fischer DR, Metzler P, Andreisek G, Nanz D, Jacobsen C, et al. Bisphosphonate-induced osteonecrosis of the jaw: Comparison of disease extent on contrast-enhanced MR imaging, [18F] fluoride PET/CT, and conebeam CT imaging. Am J Neuroradiol. 2013;34(6):1242-1247. doi: https://doi.org/10.3174/ajnr.A3355

Berg BI, Mueller AA, Augello M, Berg S, Jaquiéry C. Imaging in patients with Bisphosphonate-Associated Osteonecrosis of the Jaws (MRONJ). Dent J. 2016;4(3):29. doi: https://doi.org/10.3390/dj4030029

Arce K, Assael LA, Weissman JL, Markiewicz MR. Imaging findings in bisphosphonate-related osteonecrosis of jaws. J Oral Maxillofac Surg. 2009;67(5 Suppl.):75-84. doi: https://doi.org/10.1016/j.joms.2008.12.002

Treister N, Sheehy N, Bae EH, Friedland B, Lerman M, Woo S. Dental panoramic radiographic evaluation in bisphosphonate-associated osteonecrosis of the jaws. Oral Dis. 2009;15(1):88-92. doi: https://doi.org/10.1111/j.1601-0825.2008.01494.x

Guo Y, Wang D, Wang Y, Peng X, Guo C. Imaging features of medicine-related osteonecrosis of the jaws: comparison between panoramic radiography and computed tomography. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122(2):e69-e76. doi: https://doi.org/10.1016/j.oooo.2016.04.007

Klingelhoffer C, Klingelhoffer M, Muller S, Ettl T, Wahlmann U. Can dental panoramic radiographic findings serve as indicators for the development of medication-related osteonecrosis of the jaw? Dentomaxillofacial Radiol. 2016;45(5). doi: https://doi.org/10.1259/dmfr.20160065

Taniguchi T, Ariji Y, Nozawa M, Naioth M, Kuroiwa Y, Kurita K, et al. Computed tomographic assessment of early changes of the mandible in bisphosphonate-treated patients. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122(3):362-72. doi: https://doi.org/10.1016/j.oooo.2016.06.002

Yoneda T, Hagino H, Sugimoto T, Ohta H, Takahashi S, Soen S, et al. Antiresorptive agent-related osteonecrosis of the jaw: Position Paper 2017 of the Japanese Allied Committee on Osteonecrosis of the Jaw. J Bone Miner Metab. 2017;35(1):6-19. doi: https://doi.org/10.1007/s00774-016-0810-7

Kim KM, Rhee Y, Kwon Y, Kwon TG, Lee JK, Kim DY. medication related osteonecrosis of the jaw: 2015 Position Statement of the Korean Society for Bone and Mineral Research and the Korean Association of Oral and Maxillofacial Surgeons. J Bone Metab. 2015;22:151-65. doi: https://doi.org/10.11005/jbm.2015.22.4.151

Vassiliou V, Tselis N, Kardamakis D. Osteonecrosis of the jaws: Clinicopathologic and radiologic characteristics, preventive and therapeutic strategies. Strahlenther Onkol. 2010;186(7):367-373. doi: https://doi.org/10.1007/s00066-010-2066-9

Pautke C, Bauer F, Otto S, Tischer T, Steiner T, Weitz J, et al. Fluorescence-guided bone resection in bisphosphonate-related osteonecrosis of the jaws: First clinical results of a prospective pilot study. J Oral Maxillofac Surg. 2011;69(1):84-91. doi: https://doi.org/10.1016/j.joms.2010.07.014

Bedogni A, Fedele S, Bedogni G, Scoletta M, Favia G, Colella G, et al. Staging of osteonecrosis of the jaw requires computed tomography for accurate definition of the extent of bony disease. Br J Oral Maxillofac Surg. 2014;52(7):603-8. doi: https://doi.org/10.1016/j.bjoms.2014.04.009

Leite AF, Ogata FS, Melo NS, Figueiredo PT. Imaging findings of bisphosphonate-related osteonecrosis of the jaws: a critical review of the quantitative studies. Int J Dent. 2014;2014. doi: https://doi.org/10.1155/2014/784348

Khan AA, Morrison A, Hanley DA, Felsenborg D, McCuley LK, O’Ryan F, et al. Diagnosis and management of osteonecrosis of the jaw: A systematic review and international consensus. J Bone Miner Res. 2015;30(1):3-23. doi: https://doi.org/10.1002/jbmr.2405

Motta ACF, Macedo LD, Santos GG, Gerreiro CT, Ferrari T, Oliveira TF, et al. Quantitative ultrasound at the hand phalanges in patients with bisphosphonate-related osteonecrosis of the jaws. Braz Oral Res. 2015;29(1):1-9. doi: https://doi.org/10.1590/1807-3107BOR-2015.vol29.0106

Assaf AT, Amberg V, Smeets R, Wikner J, Hanken H, Semmusch J, et al. Evaluation of periodontal space widening in patients with antiresorptive drug-related osteonecrosis of the jaws (ARONJ) on panoramic radiographs. Anticancer Res. 2018;38(9):5305-14. doi: https://doi.org/10.21873/anticanres.12857

Barragan-Adjemian C, Lausten L, Ang DB, Johnson M, Katz J, Bonewald LF. Bisphosphonate-related osteonecrosis of the jaw: model and diagnosis with cone beam computerized tomography. Cells Tissues Organs. 2008;189(1-4):284-8. doi: https://doi.org/10.1159/000151451

Obinata K, Shirai S, Ito H, Nakamura M, Carrozzo M, Macleod I, et al. Image findings of bisphosphonate related osteonecrosis of jaws comparing with osteoradionecrosis. Dentomaxillofac Radiol. 2017;46(5):20160281. doi: https://doi.org/10.1259/dmfr.20160281

Hamada H, Matsuo A, Koizumi T, Satomi T, Chikazu D. A simple evaluation method for early detection of bisphosphonate-related osteonecrosis of the mandible using computed tomography. J Craniomaxillofac Surg. 2014;42(6):924-9. doi: https://doi.org/10.1016/j.jcms.2014.01.012

Torres SR, Chen CSK, Leroux BG, Lee PP, Hollender LG, Santos EC, et al. Mandibular cortical bone evaluation on cone beam computed tomography images of patients with bisphosphonate-related osteonecrosis of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113(5):695-703. doi: https://doi.org/10.1016/j.oooo.2011.11.011

Chiandussi S, Biasotto M, Dore F, Cavalli F, Cova MA, Di Lenarda R. Clinical and diagnostic imaging of bisphosphonate-associated osteonecrosis of the jaws. Dentomaxillofac Radiol. 2006;35(4):236-43. doi: https://doi.org/10.1259/dmfr/27458726

Drake MT, Clarke BL, Khosla S. Bisphosphonates: mechanism of action and role in clinical practice. Mayo Clin Proc. 2008;83(9):1032-45. doi: https://doi.org/10.4065/83.9.1032

Dore F, Filippi L, Biasotto M, Chiandussi S, Cavalli F, Di Lenarda R. Bone scintigraphy and SPECT/CT of bisphosphonate-induced osteonecrosis of the jaw. J Nucl Med. 2008;50(1):30-5. doi: 10.2967/jnumed.107.048785

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Published

2020-03-12

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Section

Literature review