A systematic review of the long-term effects of dental development disturbances after hematopoietic stem-cell transplantation in pediatric patients

Authors

  • Alexandre Viana Frascino Department of Oral Surgery, Faculdades Metropolitanas Unidas, São Paulo, SP
  • Fábio Luiz Coracin Oral Pathology and Medicine, Clinics Hospital, School of Medicine, University of São Paulo, São Paulo, SP
  • Paulo Sérgio da Silva Santos Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, SP

DOI:

https://doi.org/10.11606/issn.2357-8041.clrd.2014.84385

Keywords:

Bone Marrow Transplantation, Hematopoietic Stem Cell Transplantation, Child, Drug Therapy, Radiotherapy.

Abstract

The purpose of this systematic review was to evaluate published data and to update our current knowledge about the impact on dental development of childhood hematopoietic stem-cell transplantation (HSCT), as well as the late effects of preparative regimens, for the treatment of onco-hematological malignancies. A systematic literature research was conducted to assess articles published since January 1980 until the present day that fi tted the predetermined inclusion/exclusion criteria. Data compilation was divided into qualitative and quantitative dental development disturbances. Demographic records were also gathered. First and second premolars and second molars were signifi cantly more affected in HSCT children. There was a positive correlation between age at the time of anticancer therapy administration and qualitative and quantitative dental development disturbances. The association of total body or head and neck radiation mieloablative treatments was shown to enhance the magnitude of dental development disturbances. Dental development disturbances due to childhood HSCT are commonly seen in long-term survivors. The knowledge of these alterations may help improve dental care and elevate the quality of life of these patients. Further studies are needed to understand the long-term effects of dental development disturbances in this group of patients.

Downloads

Download data is not yet available.

Author Biographies

  • Fábio Luiz Coracin, Oral Pathology and Medicine, Clinics Hospital, School of Medicine, University of São Paulo, São Paulo, SP

    DMD, PhD, Oral Pathology and Medicine, Hematopoietic Stem Cell Transplantation, Clinics Hospital School of Medicine - University of São Paulo, São Paulo, Brazil. Nove de Julho University, Department of Health, São Paulo, SP, Brazil

  • Paulo Sérgio da Silva Santos, Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, SP
    DDS, MD, PhD, Department of Stomatology, Bauru School of Dentistry - University of São Paulo, São Paulo, Brazil

References

Hunger SP, Lu X, Devidas M, Camitta BM, Gaynon PS, Winick NJ, Reaman GH, et al. Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the Children’s Oncology Group. J ClinOncol2012; 30: 1663–69.

Passweg JR, Halter J, Bucher C, Gerull S, Heim D, Rovó A, et al. Hematopoietic stem cell transplantation: a review and recommendations for follow-up care for the general practitioner. Swiss Med Wkly. 2012b Oct 15;142:w13696.

Pui C-H, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet 2008; 371: 1030–43.

Marinotto AB, Rowland JH, Yabroff KR, Scoppa S, Hachey M, Ries L et al. Long-term survivors of childhood cancers in the United States. Cancer Epidemiol Biomarkers Prev 2009;18: 1033–40.

Vesterbacka M, Ringdén O, Remberger M, Huggare J, Dahllöf G. Disturbances in dental development and craniofacial growth in children treated with hematopoietic stem cell transplantation. OrthodCraniofac Res. 2012 Feb;15(1):21-9.

Haupt R, Jankovic M, Hjorth L, Skinner R. Late effects in childhood cancer survivors and survivorship issues. Unità di epidemiologia e biostatistica, Istituto G. Gaslini, Genova. Epidemiol Prev. 2013 Jan-Feb;37(1 Suppl 1):266-73.

Geenen MM, Cardous-Ubbink MC, Kremer LC, van denBos C, van der Pal HJ, Heinen RC, et al. Medical assessmentof adverse health outcomes in long-termsurvivors of childhoodcancer. AMA. 2007 Jun 27;297(24):2705-15.

Brennan BM, Shalet SM. Endocrine late effects after bone marrow transplant. Br J Haematol. 2002 Jul;118(1):58-66.

Leiper AD. Non-endocrine late complications of bone marrow transplantation in childhood: part II. Br J Haematol. 2002 Jul;118(1):23-43.

Leiper AD. Non-endocrine late complications of bone marrow transplantation in childhood: part I. Br J Haematol. 2002 Jul;118(1):3-22.

Minicucci EM, Lopes LF, Crocci AJ. Dental abnormalities in children after chemotherapy treatment for acute lymphoid leukemia. Leuk Res. 2003 Jan;27(1):45-50.

Oğuz A, Cetiner S, Karadeniz C, Alpaslan G, Alpaslan C, Pinarli G. Long-term effects of chemotherapy on orodental structures in children with non-Hodgkin's lymphoma. Eur J Oral Sci. 2004 Feb;112(1):8-11.

Cubukcu CE, Sevinir B, Ercan I. Disturbed dental development of permanent teeth in children with solid tumors and lymphomas. Pediatr Blood Cancer. 2012 Jan;58(1):80-4.

Nishimura S, Inada H, Sawa Y, Ishikawa H. Risk factors to cause tooth formation anomalies in chemotherapy of paediatric cancers. Eur J CancerCare (Engl). 2013 May;22(3):353-60.

Hölttä P, Alaluusua S, Saarinen-Pihkala UM, Wolf J, Nyström M, Hovi L. Long-term adverse effects on dentition in children with poor-risk neuroblastoma treated with high-dose chemotherapy and autologous stem cell transplantation with or without total body irradiation. Bone Marrow Transplant. 2002 Jan;29(2):121-7.

Hölttä P, Alaluusua S, Saarinen-Pihkala UM, Peltola J, Hovi L. Agenesis and microdontia of permanent teeth as late adverse effects after stem cell transplantation in young children. Cancer. 2005 Jan 1;103(1):181-90.

van der Pas-van Voskuilen IG, Veerkamp JS, Raber-Durlacher JE, Bresters D, van Wijk AJ, Barasch A, et al. Long-term adverse effects of hematopoietic stem cell transplantation on dental development in children. Support Care Cancer. 2009 Sep;17(9):1169-75.

Tanzi EM. Health-related quality of life of hematopoietic stem cell transplant childhood survivors: state of the science. J PediatrOncolNurs. 2011 Jul-Aug;28(4):191-202.

Bhatia S, Davies SM, Scott Baker K, Pulsipher MA, Hansen JA. NCI, NHLBI first international consensus conference on late effects after pediatric hematopoietic cell transplantation: etiology and pathogenesis of late effects after HCT performed in childhood-methodologic challenges. Biol Blood Marrow Transplant. 2011 Oct;17(10):1428-35.

Duggal MS. Root surfaceareas in long-termsurvivorsofchildhoodcancer. Oral Oncol. 2003 Feb;39(2):178-83.

Abe R, Endo T, Shimooka S. Maxillary first molar agenesis and other dental anomalies. Angle Orthod. 2010 Nov;80(6):1002-9. doi: 10.2319/020210-69.1.

Harada H, Kettunen P, Jung HS, Mustonen T, Wang YA, Thesleff I. Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling. J Cell Biol. 1999 Oct 4;147(1):105-20.

Thesleff I, Järvinen E, Suomalainen M. Affecting tooth morphology and renewal by fine-tuning the signals mediating cell and tissue interactions. Novartis Found Symp. 2007;284:142-53; discussion 153-63.

Brook AH. Multilevel complex interactions between genetic, epigenetic and environmental factors in the aetiology of anomalies of dental development. Arch Oral Biol. 2009 Dec;54 Suppl 1:S3-17.

Ten Cate's Oral Histology, Nanci, Elsevier, 2013, pages 70-94

Downloads

Published

2014-12-31

Issue

Vol. 20 No. 4 (2014)

Section

Systematic Review

License

Authors are requested to send, together with the letter to the Editors, a term of responsibility. Thus, the works submitted for appreciation for publication must be accompanied by a document containing the signature of each of the authors, the model of which is presented as follows:

I/We, _________________________, author(s) of the work entitled_______________, now submitted for the appreciation of Clinical and Laboratorial Research in Dentistry, agree that the authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

Date: ____/____/____Signature(s): _______________